DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbl6

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_610665.2	Gene:	Fbl6 / 36201	FlyBaseID:	FBgn0033609	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	88/393 - (22%)
Similarity:	152/393 - (38%)	Gaps:	108/393 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 IDTREWCRAFENMHNLRTLKLSG-NCHLVLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAG 352
            :|.|  |.|..:: |:...|:|. ||.|..|.:   ..|..|.|   .|:|....|::.|.|:..
  Fly   358 VDNR--CSACTDL-NVSNWKISDINCFLAKLSS---GCPNLAGI---TLSGWKGFTSDHLTYLVD 413

  Fly   353 KWQSTLKVLDL-MFCVQLNAN---------CIDALRQLSGRLEALTMAYCRELTGTGLLQGLAGD 407
            .... |:.||| ...|::||:         | :||:.:..||..|.:|:.| |.|...:.|:.
  Fly   414 NMHK-LQRLDLSSINVEMNASKSAVGVNSLC-NALQTMGSRLTHLYLAHNR-LAGIPQIVGIL-- 473

  Fly   408 INYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEY 472
                              |:.|      |||..|.|.|.....|...:..|.:.|...:.|.:
  Fly   474 ------------------STHC------PNLTLLDLSNVTTQATSHGVLHIEKLQRGCQKLKV-- 512

  Fly   473 CMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLMVGLKLPELRALSLGYCNRLTSEG 537
             :::|:..:     ||...|            .:.:.||.     ..|||..||:.   .||.|.
  Fly   513 -LRVTNSHI-----TPSTAS------------MQEIMDSP-----GFPELEELSVA---ALTDES 551

  Fly   538 FEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQS--------IHHIL 594
                               ..:.|:.:..|:.:..:|::|::.|||:||.:|        |.|:.
  Fly   552 -------------------RIISDDHLQRILKSSSKLKLLDVRNCTRLTHESLIRLPAWDIKHLF 597

  Fly   595 AHGHNLVQLIACSIDGMDHEQAQRILESQR--PQMKQVLLXQERYIHXRSRNTP--HHNDWGNHE 655
            ..|.::.:.:...::.:..:.|..::|...  ..|:|.:....|.:..:.|::|  |.|..|:..
  Fly   598 LSGCSVTRDMGSGLELIASKWAHSLIELDLAWANMQQPIDNALRALAEKGRDSPLAHLNLCGSSV 662

  Fly   656 DDE 658
            .||
  Fly   663 SDE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/13 (31%)
		LRR_RI	<297..482	CDD:238064	47/195 (24%)
		leucine-rich repeat	304..330	CDD:275381	7/26 (27%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	10/30 (33%)
		leucine-rich repeat	384..409	CDD:275381	7/24 (29%)
		leucine-rich repeat	412..437	CDD:275381	2/24 (8%)
		AMN1	430..595	CDD:187754	36/172 (21%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	5/30 (17%)
		leucine-rich repeat	497..521	CDD:275381	2/23 (9%)
		leucine-rich repeat	522..547	CDD:275381	6/24 (25%)
		leucine-rich repeat	548..573	CDD:275381	2/24 (8%)
		leucine-rich repeat	574..599	CDD:275381	11/32 (34%)
Fbl6	NP_610665.2	F-box-like	293..341	CDD:289689
		leucine-rich repeat	365..391	CDD:275381	7/29 (24%)
		leucine-rich repeat	392..417	CDD:275381	7/27 (26%)
		leucine-rich repeat	418..445	CDD:275381	8/27 (30%)
		leucine-rich repeat	453..471	CDD:275381	6/18 (33%)
		leucine-rich repeat	480..509	CDD:275381	7/28 (25%)
		leucine-rich repeat	510..538	CDD:275381	7/52 (13%)
		leucine-rich repeat	539..579	CDD:275381	12/61 (20%)
		leucine-rich repeat	580..621	CDD:275381	7/40 (18%)
		leucine-rich repeat	622..649	CDD:275381	4/26 (15%)
		leucine-rich repeat	652..676	CDD:275381	5/14 (36%)
		leucine-rich repeat	677..698	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000