DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and CG8272

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	156/669 - (23%)
Similarity:	261/669 - (39%)	Gaps:	197/669 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LPNEMWLEIMSYLSYNDLLQLRMVSWRCRDLVHRRRFMEK-----GKVIVTQH--------NLEA 129
            ||.|:.|:|.|||.|:||........|....:.:..|.::     .||:::..        ..|.
  Fly    14 LPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDLMRCER 78

  Fly   130 IHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGHEVKHLQVRHAPV----FRNLDGKLPNLK 190
            ..:|       ..||.:.|      .|::..:|.:|...:.|.:.:..:    |..:.|.||:|.
  Fly    79 RFQH-------FLFEDVTL------GQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLH 130

  Fly   191 VLTIATTM------SMDDQHLAAMDDL-DMKQFSHLVGFE----CDGVSL-DAVLKMRMLLQLRR 243
            .|::...:      |..|.:..:..|| |:.  |:|.|.:    |:...| ||:|       :|.
  Fly   131 SLSLKRCLPLFMSGSFLDSYNNSCPDLNDLA--SNLAGIKELTLCENQYLTDAIL-------MRL 186

  Fly   244 TENKVQLR-------HLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGID---------TR 292
            |.....|.       |:.|      .||:      |..       |:..:...|         |.
  Fly   187 TSFMPSLEAINMSGCHIAF------HNAI------HRR-------FYPATSSSDHVLPSESVLTF 232

  Fly   293 EWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLTGMLSLT-NELLLYVAGKWQS 356
            ::.....|:.. |||::....|.::.:|:|.....:..:::|.|.|...|. ..:|.::|  .|.
  Fly   233 KFILTILNLQR-RTLRVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLA--TQP 294

  Fly   357 TLKVLDLMFCVQLNANCIDALRQLSGRLE-------------------------ALTMAYCRELT 396
            .|..|||...:.:|...:.||.|.:.:||                         :|.::.|..||
  Fly   295 QLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLT 359

  Fly   397 GTGLLQGLAGDINYSLQELHLEETIFLDESSMC--QLLERLPNLRRLSLDNCRQAVTDRTMATIC 459
            .:|:::|:|.:.|..:|||::.   :|.....|  .:...|..||.|.|::|....||..:.::.
  Fly   360 SSGIIEGIASEENPVIQELNVS---YLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVI 421

  Fly   460 QYQTRLRNLNIEYCMKITDQGLMGYG------------------DTPYP---------------- 490
            .....||.|::|:|..:||..|.|..                  |..||
  Fly   422 GQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSL 486

  Fly   491 -------------------------------------------ISRLRGLKELNLRGCRNVTDSS 512
                                                       |.:||||:.||||||..::|.|
  Fly   487 QSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVS 551

  Fly   513 LMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVL 577
            |..|||..|||.|.|..|.:::..|.||:..:|||:|.|.:|.|..:.|:|:..:.|.|.||:.|
  Fly   552 LKYGLKHIELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKAL 616

  Fly   578 NLSNCTKLTLQSIHHILAH 596
            ::|.|::||..::..|:.:
  Fly   617 HISGCSQLTEHTLDAIITN 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	13/38 (34%)
		leucine-rich repeat	281..303	CDD:275381	4/30 (13%)
		LRR_RI	<297..482	CDD:238064	52/212 (25%)
		leucine-rich repeat	304..330	CDD:275381	6/25 (24%)
		leucine-rich repeat	331..357	CDD:275381	7/26 (27%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/49 (18%)
		leucine-rich repeat	412..437	CDD:275381	6/26 (23%)
		AMN1	430..595	CDD:187754	65/241 (27%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	14/107 (13%)
		leucine-rich repeat	497..521	CDD:275381	13/23 (57%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	8/24 (33%)
		leucine-rich repeat	574..599	CDD:275381	7/23 (30%)
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	43/175 (25%)
		leucine-rich repeat	270..295	CDD:275381	7/26 (27%)
		leucine-rich repeat	296..319	CDD:275381	8/22 (36%)
		leucine-rich repeat	322..346	CDD:275381	2/23 (9%)
		leucine-rich repeat	347..399	CDD:275381	14/54 (26%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	14/107 (13%)
		AMN1	515..>642	CDD:187754	45/121 (37%)
		leucine-rich repeat	536..560	CDD:275381	13/23 (57%)
		leucine-rich repeat	561..586	CDD:275381	9/24 (38%)
		leucine-rich repeat	587..612	CDD:275381	8/24 (33%)
		leucine-rich repeat	613..638	CDD:275381	7/23 (30%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	12/29 (41%)
		leucine-rich repeat	129..166	CDD:275381	9/38 (24%)
		leucine-rich repeat	167..192	CDD:275381	7/31 (23%)
		leucine-rich repeat	193..244	CDD:275381	10/70 (14%)
		C2	<231..274	CDD:301316	8/43 (19%)
		leucine-rich repeat	246..269	CDD:275381	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161790at33208
OrthoFinder	1	1.000	-	-		FOG0003012
OrthoInspector	1	1.000	-	-		otm45240
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750