DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and fbxl14a

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_958890.1	Gene:	fbxl14a / 333988	ZFINID:	ZDB-GENE-030131-5920	Length:	411	Species:	Danio rerio

Alignment Length:	359	Identity:	92/359 - (25%)
Similarity:	169/359 - (47%)	Gaps:	48/359 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 SCSPGIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLTGMLSLTNELLL 348
            |..|.:.||       .:..::.|.|..:     |..|::.:|.   |..|:|:|..:||:..|.
Zfish    60 SLFPSLQTR-------GIKKVQILSLRRS-----LSYVIQGMPN---IESLNLSGCYNLTDNGLG 109

  Fly   349 YVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGLL---QGLAGDINY 410
            :...:...:|::|:|..|.|:..:.:..:.|....||.|.:..|..:|.||||   .||     :
Zfish   110 HAFVQDIPSLRILNLSLCKQITDSSLGRIAQYLKNLELLDLGGCSNITNTGLLLIAWGL-----H 169

  Fly   411 SLQELHLEETIFLDESSMCQL-------LERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNL 468
            :|:.|:|.....:.:..:..|       .|....|..|:|.:| |.:||.::..|.:...:|:.|
Zfish   170 NLKSLNLRSCRHVSDVGIGHLAGMTRSAAEGCLTLEHLTLQDC-QKLTDLSLKHISKGLNKLKVL 233

  Fly   469 NIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLMVGLKLPELR--ALSLGYCN 531
            |:.:|..|:|.|::       .:|.:..|..||||.|.|::|:.:| .|.:..||  .|.:.:|:
Zfish   234 NLSFCGGISDAGMI-------HLSHMTQLWTLNLRSCDNISDTGIM-HLSMGALRLYGLDVSFCD 290

  Fly   532 RLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAH 596
            ::..:....:.|....|::|.:.|| .:.|:.:..:|..:..|:.||:..|.::|.:.:..|..|
Zfish   291 KVGDQSLAYIAQGLYQLKSLSLCSC-HISDDGINRMVRQMHELKTLNIGQCVRITDKGLELIADH 354

  Fly   597 GHNLVQLIACSIDGMDHEQAQRILE--SQRPQMK 628
               |.||....:.|.. :..:|.||  :|.|.:|
Zfish   355 ---LTQLTGIDLYGCT-KITKRGLERITQLPCLK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/18 (22%)
		LRR_RI	<297..482	CDD:238064	49/194 (25%)
		leucine-rich repeat	304..330	CDD:275381	5/25 (20%)
		leucine-rich repeat	331..357	CDD:275381	7/25 (28%)
		leucine-rich repeat	358..379	CDD:275381	5/20 (25%)
		leucine-rich repeat	384..409	CDD:275381	11/27 (41%)
		leucine-rich repeat	412..437	CDD:275381	5/31 (16%)
		AMN1	430..595	CDD:187754	45/173 (26%)
		leucine-rich repeat	438..464	CDD:275381	8/25 (32%)
		leucine-rich repeat	465..496	CDD:275381	8/30 (27%)
		leucine-rich repeat	497..521	CDD:275381	10/23 (43%)
		leucine-rich repeat	522..547	CDD:275381	5/26 (19%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	7/24 (29%)
fbxl14a	NP_958890.1	F-box-like	5..46	CDD:289689
		AMN1	90..243	CDD:187754	43/161 (27%)
		leucine-rich repeat	92..118	CDD:275381	7/25 (28%)
		leucine-rich repeat	119..144	CDD:275381	6/24 (25%)
		leucine-rich repeat	145..170	CDD:275381	11/29 (38%)
		leucine-rich repeat	171..203	CDD:275381	5/31 (16%)
		leucine-rich repeat	204..229	CDD:275381	8/25 (32%)
		AMN1	230..397	CDD:187754	46/168 (27%)
		leucine-rich repeat	230..254	CDD:275381	8/30 (27%)
		leucine-rich repeat	255..280	CDD:275381	10/25 (40%)
		leucine-rich repeat	281..304	CDD:275381	3/22 (14%)
		leucine-rich repeat	307..331	CDD:275381	6/24 (25%)
		leucine-rich repeat	332..357	CDD:275381	8/27 (30%)
		leucine-rich repeat	358..377	CDD:275381	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810