DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and CG15056

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	321	Identity:	67/321 - (20%)
Similarity:	104/321 - (32%)	Gaps:	109/321 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 WQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYC--------RELTGTGLLQGLAG-DIN 409
            |...||.|||...:...|:| |....:..|...|.::..        ..|..|.|...|:| ||.
  Fly    16 WLDVLKQLDLKSRISFAASC-DMFENIYVRSSPLRLSRVVNLEEMIEFSLLETKLFVELSGSDIE 79

  Fly   410 ------YSLQELHLEETIFLDESSMCQLLE-------------------RLPNLRRLSLDNCRQA 449
                  ::....|.|:.|.|....:.::.|                   ...||..:||..|:
  Fly    80 IIRGGPHTPMFSHFEDFIRLMSIRLTKVNEIALEGFQLTQYKWFNAPETSFSNLTYVSLRRCQ-- 142

  Fly   450 VTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLM 514
            :.|..:.. .::.|.|..|::.|..::|...||.     .|.|    |..|.:.||||:..:.|:
  Fly   143 LNDENLVG-WEFLTHLETLDLRYNDRLTGSCLMS-----LPTS----LLSLYITGCRNLCPNQLI 197

  Fly   515 VGLKLPELRALSLGYCNRLTSEG----FEALTQNCPSLEALCVSSCMAVDDE------------- 562
            ...::|.||.|.   .:.|...|    :..|...||.|..:.:|.|....||
  Fly   198 FLNRIPRLRELR---ASDLMPGGHWHIYRDLVLACPLLVMVEISICSLNRDEYRLGELRYLQSLV 259

  Fly   563 ------------------------------------------TVLNIVSNLKRLRVLNLSN 581
                                                      ..|:|:|..::||||.:.|
  Fly   260 IKAHSTDTIRCKVSDWMLISLLDVPFLRNLMFSDAPSGFVSANALSIISRFRQLRVLKMPN 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	34/161 (21%)
		leucine-rich repeat	304..330	CDD:275381
		leucine-rich repeat	331..357	CDD:275381	1/2 (50%)
		leucine-rich repeat	358..379	CDD:275381	8/20 (40%)
		leucine-rich repeat	384..409	CDD:275381	7/33 (21%)
		leucine-rich repeat	412..437	CDD:275381	5/43 (12%)
		AMN1	430..595	CDD:187754	45/230 (20%)
		leucine-rich repeat	438..464	CDD:275381	5/25 (20%)
		leucine-rich repeat	465..496	CDD:275381	8/30 (27%)
		leucine-rich repeat	497..521	CDD:275381	7/23 (30%)
		leucine-rich repeat	522..547	CDD:275381	7/28 (25%)
		leucine-rich repeat	548..573	CDD:275381	8/79 (10%)
		leucine-rich repeat	574..599	CDD:275381	5/8 (63%)
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	5/25 (20%)
		leucine-rich repeat	157..179	CDD:275381	7/26 (27%)
		leucine-rich repeat	180..204	CDD:275381	7/23 (30%)
		leucine-rich repeat	205..231	CDD:275381	7/28 (25%)
		leucine-rich repeat	232..285	CDD:275381	5/52 (10%)
		leucine-rich repeat	286..326	CDD:275381	8/35 (23%)
		AMN1	306..>376	CDD:187754	7/15 (47%)
		leucine-rich repeat	337..362	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830