DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl4

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001382505.1	Gene:	Fbxl4 / 313101	RGDID:	1305724	Length:	621	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	119/543 - (21%)
Similarity:	207/543 - (38%)	Gaps:	143/543 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VIVTQHNLEAIHKHAKGGNCYLSFERIELR------------NLRQCRQLE----------NFLR 162
            |:.|.|....|...|...|.|......|:|            |..|.||.:          |.:|
  Rat   142 VLETYHPGAVIRILACSANPYSPNPPAEVRWETLWSERPTKVNASQARQFKPRIKQINFPTNLIR 206

  Fly   163 LVGHEVKHLQVRHAPVFRNLDGKL----PNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFE 223
            |   ||....:.:   :..||..:    .:..:|::.|.       |..|:||:...:.     |
  Rat   207 L---EVNSSLLDY---YTELDAVVLHGTKDKPLLSLKTA-------LVDMNDLEDDDYE-----E 253

  Fly   224 CDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDH---------AETLVCV 279
            .||..:||:.|......|....:......|.:|        |:.::.:|         |:|  |.
  Rat   254 KDGCEMDALNKKFSSATLGDGPSNGYFDKLPYE--------LIQLILNHLSLPDLCRLAQT--CR 308

  Fly   280 NLFFSCSPGIDTREWCRAFENMH-NLRT--LKLSGNCHLVLLEAVLRAVPESAPIRQLDLT---- 337
            .|...|         |...:.:| ||:.  .||. :..|..|:|      ..|.::.|:|:
  Rat   309 LLHQHC---------CDPLQYIHLNLQPYWAKLD-DTSLEFLQA------RCALVQWLNLSWTGN 357

  Fly   338 -GMLSLTN-ELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGL 400
             |.:|::. ...|.|.|   |.|..|:|.....||..|::.:.::...|:.|.::.|.:|.....
  Rat   358 RGFISVSGFSRFLKVCG---SELVRLELSCSHFLNDACLEVISEMCPNLQDLNLSSCDKLPPQAF 419

  Fly   401 LQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRL 465
                 |.|                        .:|.:|:||.|  .|..|....:.:|..:...|
  Rat   420 -----GHI------------------------AKLRSLKRLIL--YRTKVEQTALLSILNFCAEL 453

  Fly   466 RNLNIEYCMKITD----QGLMGYGDTPYPISRLRGLKELNLRGCRNVTD---SSLMVGLKLPELR 523
            ::|::..|:.|.|    ..::|        ::.:.|:.|:|..|:|:|:   :.|..|..|  |.
  Rat   454 QHLSLGSCVMIEDYDVIASMIG--------AKCKSLRTLDLWRCKNITENGIAELASGCAL--LE 508

  Fly   524 ALSLGYCNRLTSEG--FEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLT 586
            .|.||:|..|.|..  |..|.:..|:|:.|.:::..:|.|..:..:.||..||:.|::.....::
  Rat   509 ELDLGWCPTLQSSTGCFARLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDILGTRMVS 573

  Fly   587 LQSIHHIL--AHGHNLVQLIACS 607
            ..|:..:|  ....:|:.:..||
  Rat   574 PASLRKLLESCKDLSLLDVSFCS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/22 (18%)
		LRR_RI	<297..482	CDD:238064	42/197 (21%)
		leucine-rich repeat	304..330	CDD:275381	6/27 (22%)
		leucine-rich repeat	331..357	CDD:275381	7/31 (23%)
		leucine-rich repeat	358..379	CDD:275381	6/20 (30%)
		leucine-rich repeat	384..409	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	1/24 (4%)
		AMN1	430..595	CDD:187754	44/175 (25%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	6/34 (18%)
		leucine-rich repeat	497..521	CDD:275381	9/26 (35%)
		leucine-rich repeat	522..547	CDD:275381	9/26 (35%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	4/26 (15%)
Fbxl4	NP_001382505.1	F-box-like	280..318	CDD:403981	10/56 (18%)
		leucine-rich repeat	295..317	CDD:275381	6/32 (19%)
		leucine-rich repeat	318..340	CDD:275381	6/22 (27%)
		leucine-rich repeat	347..376	CDD:275381	7/31 (23%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		AMN1	394..601	CDD:187754	53/244 (22%)
		leucine-rich repeat	403..427	CDD:275381	7/52 (13%)
		leucine-rich repeat	428..452	CDD:275381	7/25 (28%)
		leucine-rich repeat	453..480	CDD:275381	6/34 (18%)
		leucine-rich repeat	481..506	CDD:275381	8/24 (33%)
		leucine-rich repeat	507..534	CDD:275381	9/26 (35%)
		leucine-rich repeat	535..560	CDD:275381	6/24 (25%)
		leucine-rich repeat	561..586	CDD:275381	4/24 (17%)
		leucine-rich repeat	587..612	CDD:275381	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740