DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl15

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001101073.1	Gene:	Fbxl15 / 309453	RGDID:	1306444	Length:	300	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	73/272 - (26%)
Similarity:	113/272 - (41%)	Gaps:	31/272 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 ESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLS-GRLEALTMA 390
            |...:|.|||.     ..::||.....|....::|.|    |..:....||.||. .||.....|
  Rat    13 EPGAVRLLDLP-----WEDVLLPHVLNWVPLRQLLRL----QRVSRAFRALVQLHLARLRRFDAA 68

  Fly   391 YCRELTGTGLLQGLAGDINYSLQELHLE--ETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDR 453
            ..........|..|..|.. .||||.|.  ....||| .:..:|.|.|.||.::|..|.| ::.|
  Rat    69 QVGPQIPRAALVRLLRDAE-GLQELALAPCHEWLLDE-DLVPVLARNPQLRSVALAGCGQ-LSRR 130

  Fly   454 TMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSL--MVG 516
            .:..:.:...||:.:::.:|..:....|.|..|      |...|:||:|..||.:.|.::  :..
  Rat   131 ALGALAEGCPRLQRISLAHCDWVDGLALRGLAD------RCPALEELDLTACRQLKDEAIVYLAQ 189

  Fly   517 LKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSN 581
            .:...||:|||.....:.....:.|.:|||.||.|.::.|:.|..:.|..:......||.|.:.:
  Rat   190 RRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRH 254

  Fly   582 CTKLTLQSIHHI 593
            |        ||:
  Rat   255 C--------HHV 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	41/157 (26%)
		leucine-rich repeat	304..330	CDD:275381	1/2 (50%)
		leucine-rich repeat	331..357	CDD:275381	7/25 (28%)
		leucine-rich repeat	358..379	CDD:275381	5/20 (25%)
		leucine-rich repeat	384..409	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	10/26 (38%)
		AMN1	430..595	CDD:187754	44/166 (27%)
		leucine-rich repeat	438..464	CDD:275381	6/25 (24%)
		leucine-rich repeat	465..496	CDD:275381	6/30 (20%)
		leucine-rich repeat	497..521	CDD:275381	7/25 (28%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	6/20 (30%)
Fbxl15	NP_001101073.1	F-box	18..55	CDD:395521	11/45 (24%)
		leucine-rich repeat	62..88	CDD:275381	5/26 (19%)
		leucine-rich repeat	89..115	CDD:275381	10/26 (38%)
		Interaction with SMURF1. /evidence=ECO:0000250	113..269		42/161 (26%)
		leucine-rich repeat	116..141	CDD:275381	6/25 (24%)
		AMN1	<139..>268	CDD:187754	35/134 (26%)
		leucine-rich repeat	142..167	CDD:275381	6/30 (20%)
		leucine-rich repeat	168..194	CDD:275381	7/25 (28%)
		leucine-rich repeat	195..220	CDD:275381	8/24 (33%)
		leucine-rich repeat	221..245	CDD:275381	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910