DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12402 and Fbxl6

DIOPT Version :9

Sequence 1:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_038937.2 Gene:Fbxl6 / 30840 MGIID:1354705 Length:535 Species:Mus musculus


Alignment Length:323 Identity:75/323 - (23%)
Similarity:110/323 - (34%) Gaps:106/323 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   304 LRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDL-------TGMLSLTNELLLYVAGKW----QST 357
            |..|||| :||.|..|.::........:..|||       |.::|...|....:...|    ..|
Mouse   214 LTFLKLS-DCHTVTAETLVMLARACCQLHSLDLHHSMVESTAVVSFLEEAGSRMRKLWLTYSSQT 277

  Fly   358 LKVLDLMF---CVQLNA-------NC--------IDALRQLSGRLEA---LTMAYCRELTGTGLL 401
            ..:|..:.   |.||..       ||        ::||::...:|:.   |.:.:..:..|.|:.
Mouse   278 TAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPVEALQKGCPQLQVLRLLNLIWLPKPCGRGVP 342

  Fly   402 QGLAGDINYSLQELHLEETI--FLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQ---- 460
            ||....   ||:||.|..:.  |:....:.:||.|.|.||.|.|..|.:..........||    
Mouse   343 QGPGFP---SLEELCLAGSTCNFVSNEVLGRLLHRSPKLRMLDLRGCARVTPSGLCHLPCQELEQ 404

  Fly   461 --------------------------YQTRLRNLNIE---YCMKITDQGLMGYGDTP---YPISR 493
                                      |.| ||.|:..   :..|..:|.|..:..||   :|   
Mouse   405 LYLGLYGISDGLTLAKDGSPLLTRKWYHT-LRELDFSGQGFSEKDLEQALAVFSGTPGGLHP--- 465

  Fly   494 LRGLKELNLRGCRNVTDSSLMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSC 556
              .|..|||||.| ||.|::                         .::...||.|..|.:.||
Mouse   466 --ALCSLNLRGTR-VTPSTV-------------------------SSVISGCPGLLYLNLESC 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12402NP_001303481.1 F-box 75..117 CDD:279040
leucine-rich repeat 281..303 CDD:275381
LRR_RI <297..482 CDD:238064 55/244 (23%)
leucine-rich repeat 304..330 CDD:275381 9/25 (36%)
leucine-rich repeat 331..357 CDD:275381 7/36 (19%)
leucine-rich repeat 358..379 CDD:275381 8/38 (21%)
leucine-rich repeat 384..409 CDD:275381 6/27 (22%)
leucine-rich repeat 412..437 CDD:275381 8/26 (31%)
AMN1 430..595 CDD:187754 38/163 (23%)
leucine-rich repeat 438..464 CDD:275381 8/55 (15%)
leucine-rich repeat 465..496 CDD:275381 9/36 (25%)
leucine-rich repeat 497..521 CDD:275381 10/23 (43%)
leucine-rich repeat 522..547 CDD:275381 1/24 (4%)
leucine-rich repeat 548..573 CDD:275381 4/9 (44%)
leucine-rich repeat 574..599 CDD:275381
Fbxl6NP_038937.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..99
F-box-like 105..155 CDD:289689
LRR 1 169..195
AMN1 171..390 CDD:187754 46/179 (26%)
leucine-rich repeat 188..213 CDD:275381
LRR 2 196..221 5/7 (71%)
leucine-rich repeat 214..239 CDD:275381 9/25 (36%)
LRR 3 222..247 7/24 (29%)
leucine-rich repeat 240..291 CDD:275381 10/50 (20%)
LRR 4 273..299 5/25 (20%)
leucine-rich repeat 292..321 CDD:275381 5/28 (18%)
LRR 5 304..329 3/24 (13%)
leucine-rich repeat 322..349 CDD:275381 6/29 (21%)
LRR 6 330..357 9/29 (31%)
AMN1 <349..500 CDD:187754 42/182 (23%)
leucine-rich repeat 350..377 CDD:275381 8/26 (31%)
LRR 7 360..385 9/24 (38%)
leucine-rich repeat 378..401 CDD:275381 6/22 (27%)
LRR 8 386..411 3/24 (13%)
LRR 9 415..441 5/26 (19%)
leucine-rich repeat 434..466 CDD:275381 9/36 (25%)
leucine-rich repeat 467..491 CDD:275381 11/49 (22%)
LRR 10 474..499 9/50 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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