DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_038951543.1	Gene:	Fbxl21 / 306750	RGDID:	1305555	Length:	460	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	114/593 - (19%)
Similarity:	188/593 - (31%)	Gaps:	185/593 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SYNDLLQLRMVSWRCRDLVHRRRFMEKGKVIVTQHNLEAIHKHAKGGNCYLSFERIELRNLRQCR 155
            ||..|  .|...|.....:.|..|....||:   |:..|: |..|.|.|         .:|||.:
  Rat    11 SYPQL--SRNCDWETTFGMKRNNFSTVNKVV---HSSPAV-KQPKRGLC---------TSLRQTQ 60

  Fly   156 QLENFLRLVGHEVKHLQVRHAPVFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLV 220
            .|...|..                    |.||:..:|.|...:.:.|:..|:.......:..|:.
  Rat    61 MLSALLDW--------------------GTLPHHVILRIFQYLPLVDRARASSVCRSWNEVFHIP 105

  Fly   221 GFECDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFE--------FRRNNENALLDVLQDHAETLV 277
            ..                           .|..:||        |:..:.:.:..:::.||..|.
  Rat   106 DL---------------------------WRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQ 143

  Fly   278 CVNLFFSCSPGIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLTGMLSL 342
            .|:  |......::.|     ...|.|..|.   ||.:..|..:..|.|....:.:......|:
  Rat   144 YVS--FKVDSSTESAE-----AACHILSQLV---NCSIQTLGLISTAKPSFMNMPKSHFVSALT- 197

  Fly   343 TNELLLYVAGKWQSTLKVLD-------LMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGL 400
                :::|..|..|::|:.|       |...|   ||..|.||       .|.|:.|..::..|:
  Rat   198 ----VVFVNSKSLSSIKIEDTPVDDPSLKILV---ANNSDTLR-------LLKMSSCPHVSSDGI 248

  Fly   401 LQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQ--------AVTDRTMAT 457
            |  ...|....|:||.|...|..||..:....|...||..|.:|...:        ::...:...
  Rat   249 L--CVADHCQGLRELALNYYILSDELLLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKPSWDA 311

  Fly   458 ICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLR-GLKELNLRGCRNVTDSSL-MVGLKLP 520
            :.::..   .:|:.....:.::....:.....|::.|. |         |:|:.:.| .:||
  Rat   312 LVKHSP---GVNVVMYFFLYEEEFDTFFKEETPVTHLYFG---------RSVSRTILGRIGL--- 361

  Fly   521 ELRALSLGYCNRLTSEGFEALTQNCPSLEAL--CVSSCMAVDDETVLNIVSNLKRLRVLNLSNCT 583
                                   |||.|..|  |.:....:|.| ::.|..:.|.|..|.||.|.
  Rat   362 -----------------------NCPRLIELVVCANGLQPLDSE-LIRIAEHCKNLTALGLSECE 402

  Fly   584 KLTLQSIHHILAHGHNLVQLIACSIDGMDHEQAQRILESQRPQMKQVLLXQERYIHXRSRNTPH- 647
            ......:..:...|..|.||                     ..|::||:..:||       ||.
  Rat   403 VSCSAFVEFVRLCGRRLTQL---------------------SLMEEVLVPDDRY-------TPDE 439

  Fly   648 -HNDWGNH 654
             |.:...|
  Rat   440 VHTEVSKH 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	7/25 (28%)
		leucine-rich repeat	281..303	CDD:275381	2/21 (10%)
		LRR_RI	<297..482	CDD:238064	40/199 (20%)
		leucine-rich repeat	304..330	CDD:275381	7/25 (28%)
		leucine-rich repeat	331..357	CDD:275381	3/25 (12%)
		leucine-rich repeat	358..379	CDD:275381	8/27 (30%)
		leucine-rich repeat	384..409	CDD:275381	6/24 (25%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		AMN1	430..595	CDD:187754	29/176 (16%)
		leucine-rich repeat	438..464	CDD:275381	3/33 (9%)
		leucine-rich repeat	465..496	CDD:275381	3/31 (10%)
		leucine-rich repeat	497..521	CDD:275381	5/24 (21%)
		leucine-rich repeat	522..547	CDD:275381	2/24 (8%)
		leucine-rich repeat	548..573	CDD:275381	6/26 (23%)
		leucine-rich repeat	574..599	CDD:275381	6/24 (25%)
Fbxl21	XP_038951543.1	F-box-like	68..111	CDD:403981	9/89 (10%)
		leucine-rich repeat	206..231	CDD:275381	7/27 (26%)
		leucine-rich repeat	232..257	CDD:275381	8/33 (24%)
		leucine-rich repeat	258..283	CDD:275381	8/24 (33%)
		leucine-rich repeat	284..318	CDD:275381	3/36 (8%)
		leucine-rich repeat	329..365	CDD:275381	10/70 (14%)
		AMN1	<359..>424	CDD:187754	21/112 (19%)
		leucine-rich repeat	366..392	CDD:275381	6/26 (23%)
		leucine-rich repeat	393..418	CDD:275381	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900