DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Amn1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001008334.2	Gene:	Amn1 / 302032	RGDID:	1308119	Length:	258	Species:	Rattus norvegicus

Alignment Length:	228	Identity:	64/228 - (28%)
Similarity:	113/228 - (49%)	Gaps:	44/228 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 LDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMK----ITDQGLMG 483
            :.:|::.::|.  |.::||.|.:|.  ::|..:..:|:.: :|:.||::.|.:    ||.:|:..
  Rat    50 ITDSNINEVLH--PEVQRLDLRSCN--ISDVALQHLCKCR-KLKALNLKSCREHRNSITSEGIKA 109

  Fly   484 YGDTPYPISRLRGLKELNLRGCRNVTDSS-LMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPS 547
            ..      |....|.|::|:||.:|||.. |.:.|....|:.:.||.|..:|.|...||.:|||.
  Rat   110 VA------SSCSDLHEISLKGCCSVTDEGVLALALNCQLLKIIDLGGCLSITDESLHALGKNCPF 168

  Fly   548 LEALCVS-SCMAVDDETVLNIVSN--LKRLRVLNLSNCTKLTLQSIHH----------ILAHGHN 599
            |:  ||. |...|.|..|:.:||.  .|:|..:|:..|..||.:::..          :|.||..
  Rat   169 LQ--CVDFSTTQVSDNGVVALVSGPCAKQLEEINMGYCINLTDKAVEAALTACPQICILLFHGCP 231

  Fly   600 LVQLIACSIDGMDH--EQAQRILESQRPQMKQV 630
            |:         .||  |..::::.|::  :|||
  Rat   232 LI---------TDHSREVLEQLIGSRK--LKQV 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	16/62 (26%)
		leucine-rich repeat	304..330	CDD:275381
		leucine-rich repeat	331..357	CDD:275381
		leucine-rich repeat	358..379	CDD:275381
		leucine-rich repeat	384..409	CDD:275381
		leucine-rich repeat	412..437	CDD:275381	2/13 (15%)
		AMN1	430..595	CDD:187754	52/182 (29%)
		leucine-rich repeat	438..464	CDD:275381	6/25 (24%)
		leucine-rich repeat	465..496	CDD:275381	8/34 (24%)
		leucine-rich repeat	497..521	CDD:275381	10/24 (42%)
		leucine-rich repeat	522..547	CDD:275381	10/24 (42%)
		leucine-rich repeat	548..573	CDD:275381	9/27 (33%)
		leucine-rich repeat	574..599	CDD:275381	8/34 (24%)
Amn1	NP_001008334.2	leucine-rich repeat	10..35	CDD:275381
		leucine-rich repeat	36..58	CDD:275381	1/7 (14%)
		AMN1	37..257	CDD:187754	64/228 (28%)
		leucine-rich repeat	63..86	CDD:275381	6/25 (24%)
		leucine-rich repeat	87..116	CDD:275381	8/34 (24%)
		leucine-rich repeat	117..142	CDD:275381	10/24 (42%)
		leucine-rich repeat	143..168	CDD:275381	10/24 (42%)
		leucine-rich repeat	169..195	CDD:275381	9/27 (33%)
		leucine-rich repeat	196..221	CDD:275381	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900