DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12402 and FBXL4

DIOPT Version :9

Sequence 1:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_001265645.1 Gene:FBXL4 / 26235 HGNCID:13601 Length:621 Species:Homo sapiens


Alignment Length:540 Identity:114/540 - (21%)
Similarity:208/540 - (38%) Gaps:137/540 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 VIVTQHNLEAIHKHAKGGNCYLSFERIELR------------NLRQCRQLE----------NFLR 162
            |:.|.|....|...|...|.|......|:|            |..|.||.:          |.:|
Human   142 VLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPTKVNASQARQFKPCIKQINFPTNLIR 206

  Fly   163 LVGHEVKHLQVRHAPVFRNLDG-KLPNLK---VLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFE 223
            |   ||....:.:   :..||. .|..:|   ||::.|:       |..|:|::...::     |
Human   207 L---EVNSSLLEY---YTELDAVVLHGVKDKPVLSLKTS-------LIDMNDIEDDAYA-----E 253

  Fly   224 CDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPG 288
            .||..:|::.|......|....|......|.:|        |:.::.:|........|..:|.  
Human   254 KDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYE--------LIQLILNHLTLPDLCRLAQTCK-- 308

  Fly   289 IDTREWCRAFENMH-NLR---------TLK-LSGNCHLVLLEAVLRAVPESAPIRQLDLT----- 337
            :.::..|...:.:| ||:         :|: |...|.||               :.|:|:     
Human   309 LLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLV---------------QWLNLSWTGNR 358

  Fly   338 GMLSLTN-ELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGLL 401
            |.:|:.. ...|.|.|   |.|..|:|.....||..|::.:.::...|:||.::.|.:|....  
Human   359 GFISVAGFSRFLKVCG---SELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQA-- 418

  Fly   402 QGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLR 466
                  .|:                     :.:|.:|:||.|  .|..|....:.:|..:.:.|:
Human   419 ------FNH---------------------IAKLCSLKRLVL--YRTKVEQTALLSILNFCSELQ 454

  Fly   467 NLNIEYCMKITD----QGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLM-VGLKLPELRALS 526
            :|::..|:.|.|    ..::|        ::.:.|:.|:|..|:|:|::.:. :....|.|..|.
Human   455 HLSLGSCVMIEDYDVIASMIG--------AKCKKLRTLDLWRCKNITENGIAELASGCPLLEELD 511

  Fly   527 LGYCNRLTSEG--FEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQS 589
            ||:|..|.|..  |..|....|:|:.|.:::..:|.|..:..:..|..||:.|::.....::..|
Human   512 LGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPAS 576

  Fly   590 IHHIL--AHGHNLVQLIACS 607
            :..:|  ....:|:.:..||
Human   577 LRKLLESCKDLSLLDVSFCS 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12402NP_001303481.1 F-box 75..117 CDD:279040
leucine-rich repeat 281..303 CDD:275381 4/22 (18%)
LRR_RI <297..482 CDD:238064 41/205 (20%)
leucine-rich repeat 304..330 CDD:275381 6/35 (17%)
leucine-rich repeat 331..357 CDD:275381 7/31 (23%)
leucine-rich repeat 358..379 CDD:275381 6/20 (30%)
leucine-rich repeat 384..409 CDD:275381 5/24 (21%)
leucine-rich repeat 412..437 CDD:275381 1/24 (4%)
AMN1 430..595 CDD:187754 41/173 (24%)
leucine-rich repeat 438..464 CDD:275381 7/25 (28%)
leucine-rich repeat 465..496 CDD:275381 6/34 (18%)
leucine-rich repeat 497..521 CDD:275381 6/24 (25%)
leucine-rich repeat 522..547 CDD:275381 9/26 (35%)
leucine-rich repeat 548..573 CDD:275381 5/24 (21%)
leucine-rich repeat 574..599 CDD:275381 4/26 (15%)
FBXL4NP_001265645.1 F-box-like 280..318 CDD:315592 7/47 (15%)
leucine-rich repeat 295..317 CDD:275381 3/23 (13%)
leucine-rich repeat 318..346 CDD:275381 6/27 (22%)
leucine-rich repeat 347..376 CDD:275381 8/46 (17%)
LRR 1 376..397 6/20 (30%)
leucine-rich repeat 377..398 CDD:275381 6/20 (30%)
AMN1 394..601 CDD:332986 50/242 (21%)
LRR 2 402..421 5/26 (19%)
leucine-rich repeat 403..427 CDD:275381 7/52 (13%)
LRR 3 427..448 7/22 (32%)
leucine-rich repeat 428..452 CDD:275381 7/25 (28%)
LRR 4 452..474 5/21 (24%)
leucine-rich repeat 453..480 CDD:275381 6/34 (18%)
LRR 5 480..501 6/20 (30%)
leucine-rich repeat 481..506 CDD:275381 6/24 (25%)
LRR 6 504..524 8/19 (42%)
leucine-rich repeat 507..534 CDD:275381 9/26 (35%)
LRR 7 532..558 5/25 (20%)
leucine-rich repeat 535..560 CDD:275381 5/24 (21%)
LRR 8 559..583 5/23 (22%)
leucine-rich repeat 561..586 CDD:275381 4/24 (17%)
LRR 9 584..609 3/13 (23%)
leucine-rich repeat 587..612 CDD:275381 3/10 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152301
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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