DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and FBXL2

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001336245.1	Gene:	FBXL2 / 25827	HGNCID:	13598	Length:	454	Species:	Homo sapiens

Alignment Length:	411	Identity:	100/411 - (24%)
Similarity:	160/411 - (38%)	Gaps:	129/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 RAFENMHN-----LRTLKLSGNCHLVLLEAVLRAVPESA-PIRQLDLTGMLSLTNELLLYVAGKW 354
            |..||:..     ||.|.|.| | :.:.::.|:...::. .|..|:|.|...:|:. ..|...::
Human    67 RVVENISKRCGGFLRKLSLRG-C-IGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS-TCYSLSRF 128

  Fly   355 QSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTG---LLQGLAGDINYSLQELH 416
            .|.||.|||..||.:..:.:..:.:....||.|.:::|.::|..|   |::|..|
Human   129 CSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRG---------- 183

  Fly   417 LEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGL 481
                                 |:.|.|..|.| :.|..:..|..|...|.:||::.|.:|||:|:
Human   184 ---------------------LKALLLRGCTQ-LEDEALKHIQNYCHELVSLNLQSCSRITDEGV 226

  Fly   482 MGYGDTPYPISRLRG---LKELNLRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALT 542
                     :...||   |:.|.|.||.|:||:|| .:||..|.|:.|....|:.||..||..|.
Human   227 ---------VQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLA 282

  Fly   543 QNCPSLEALCVSSCMAVDDETVL------------------NIVSNLK----------------- 572
            :||..||.:.:..|:.:.|.|::                  :|:..||
Human   283 RNCHELEKMDLEECILITDSTLIQLSIHCPKLQALVSLSFSDIIHLLKMKEPSHHNKKLFGFSFC 347

  Fly   573 -------------------------RLRVLNLSNCTKLTLQSIHHI-LAHGHNLVQLIACSIDGM 611
                                     |||||.|.||..:|..::.|: ...|...::|..|
Human   348 KSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDC----- 407

  Fly   612 DHEQAQRI----LESQRPQMK 628
              :|..|.    :.:|.|.:|
Human   408 --QQVTRAGIKRMRAQLPHVK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	3/6 (50%)
		LRR_RI	<297..482	CDD:238064	48/193 (25%)
		leucine-rich repeat	304..330	CDD:275381	7/26 (27%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	412..437	CDD:275381	0/24 (0%)
		AMN1	430..595	CDD:187754	59/229 (26%)
		leucine-rich repeat	438..464	CDD:275381	8/25 (32%)
		leucine-rich repeat	465..496	CDD:275381	8/30 (27%)
		leucine-rich repeat	497..521	CDD:275381	12/24 (50%)
		leucine-rich repeat	522..547	CDD:275381	10/24 (42%)
		leucine-rich repeat	548..573	CDD:275381	8/84 (10%)
		leucine-rich repeat	574..599	CDD:275381	10/25 (40%)
FBXL2	NP_001336245.1	F-box-like	15..56	CDD:315592
		leucine-rich repeat	52..79	CDD:275381	3/11 (27%)
		AMN1	<76..223	CDD:332986	43/181 (24%)
		leucine-rich repeat	80..99	CDD:275381	7/20 (35%)
		leucine-rich repeat	106..131	CDD:275381	6/25 (24%)
		leucine-rich repeat	132..157	CDD:275381	7/24 (29%)
		leucine-rich repeat	158..183	CDD:275381	8/24 (33%)
		AMN1	168..398	CDD:332986	64/270 (24%)
		leucine-rich repeat	184..209	CDD:275381	8/25 (32%)
		leucine-rich repeat	210..235	CDD:275381	10/33 (30%)
		leucine-rich repeat	236..261	CDD:275381	12/24 (50%)
		leucine-rich repeat	262..287	CDD:275381	10/24 (42%)
		leucine-rich repeat	288..313	CDD:275381	5/24 (21%)
		leucine-rich repeat	314..364	CDD:275381	3/49 (6%)
		leucine-rich repeat	374..393	CDD:275381	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010