DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12402 and KDM2A

DIOPT Version :9

Sequence 1:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_036440.1 Gene:KDM2A / 22992 HGNCID:13606 Length:1162 Species:Homo sapiens


Alignment Length:674 Identity:124/674 - (18%)
Similarity:238/674 - (35%) Gaps:171/674 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SLITSGKPSQRREKRLFERLSCSYAQT--------------PNRMELNLNPLLAIARSIAAPPTP 54
            |.|.||  ::||..|..:..:|...:.              |.||:.:     .:.|...||..|
Human   558 SPIVSG--ARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQS-----CVLRQCLAPRLP 615

  Fly    55 PPTP----EKLDSDKDKEGSSKAAIE-LLPNEMWLEIMSYLSYNDLLQLRMVS-WRCRDLVHRRR 113
            ....    .::|.:::.:...|..:| .:.||:.......:....||...:.: |.|     .:.
Human   616 HSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWEC-----PKC 675

  Fly   114 FMEKGKVIVTQHNLEAIHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGHE-VKHLQVRHAP 177
            :.|.......:..:|...:           |.::.:.||..|..:..|....|. ...||:.|.|
Human   676 YQEDSSEKAQKRKMEESDE-----------EAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDP 729

  Fly   178 VFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLR 242
            |       .|...|...:......|.|.|:.|:.                     .|.|.||:|:
Human   730 V-------SPRGMVTRSSPGAGPSDHHSASRDER---------------------FKRRQLLRLQ 766

  Fly   243 RTENKVQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFENMHNLRTL 307
            .|| :..:|.     :.||.:...::  ...|.......:.:.:....|:|              
Human   767 ATE-RTMVRE-----KENNPSGKKEL--SEVEKAKIRGSYLTVTLQRPTKE-------------- 809

  Fly   308 KLSGNCHLVLLEAVL----------RAVPESAPIR------------------------------ 332
             |.|...:..|:|:.          |.:.:..|.|                              
Human   810 -LHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEG 873

  Fly   333 ---QLDLTGMLSLTNELLLYVAGKWQSTLKVL---DLMFCVQLNAN----CIDALRQLSGRLEAL 387
               :|:..|..:...:........|.|..:.|   :|..|:::...    |.|  ::|..:::  
Human   874 GAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCD--KRLWTKID-- 934

  Fly   388 TMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTD 452
             ::.|:.:    :.|.|:|.|......|.|..| .:.:..:..|:.|||.|:.|.|..|..:...
Human   935 -LSRCKAI----VPQALSGIIKRQPVSLDLSWT-NISKKQLTWLVNRLPGLKDLLLAGCSWSAVS 993

  Fly   453 RTMATICQYQTRLRNLNIEYCMKITDQGLMGY----GDTPYP--ISRLRGLKELNLRGCRNVTDS 511
            ....:.|..   ||.|::.:.:.|.|..:...    .|.|..  .|:||.:.:..|.|. ::||:
Human   994 ALSTSSCPL---LRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGL-DITDA 1054

  Fly   512 SLMVGLK-LPELRALSLGYCNRLTSEGFEALT----QNCPSLEALCVSSCMAVDDETVLNIVSNL 571
            :|.:.:: :|.|..|.|.:|:.||.:....||    ....||..|.::.|..:.|:|:: .:..:
Human  1055 TLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLI-YLRRI 1118

  Fly   572 KRLRVLNLSNCTKLTLQSIHHILA 595
            ..:.:::|..|.::|.::..|.::
Human  1119 ANVTLIDLRGCKQITRKACEHFIS 1142

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12402NP_001303481.1 F-box 75..117 CDD:279040 7/43 (16%)
leucine-rich repeat 281..303 CDD:275381 2/21 (10%)
LRR_RI <297..482 CDD:238064 39/234 (17%)
leucine-rich repeat 304..330 CDD:275381 5/35 (14%)
leucine-rich repeat 331..357 CDD:275381 4/58 (7%)
leucine-rich repeat 358..379 CDD:275381 5/27 (19%)
leucine-rich repeat 384..409 CDD:275381 4/24 (17%)
leucine-rich repeat 412..437 CDD:275381 6/24 (25%)
AMN1 430..595 CDD:187754 43/175 (25%)
leucine-rich repeat 438..464 CDD:275381 5/25 (20%)
leucine-rich repeat 465..496 CDD:275381 9/36 (25%)
leucine-rich repeat 497..521 CDD:275381 5/24 (21%)
leucine-rich repeat 522..547 CDD:275381 8/28 (29%)
leucine-rich repeat 548..573 CDD:275381 5/24 (21%)
leucine-rich repeat 574..599 CDD:275381 4/22 (18%)
KDM2ANP_036440.1 cupin_like 199..299 CDD:328732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 367..389
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..557
zf-CXXC <576..609 CDD:251032 5/37 (14%)
PHD_KDM2A 619..675 CDD:277113 9/60 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..789 24/120 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..887 4/47 (9%)
F-box-like 896..934 CDD:315592 8/39 (21%)
leucine-rich repeat 930..954 CDD:275381 5/30 (17%)
AMN1 932..1138 CDD:332986 50/218 (23%)
leucine-rich repeat 955..978 CDD:275381 6/23 (26%)
LRR 1 961..982 6/21 (29%)
leucine-rich repeat 979..1002 CDD:275381 5/22 (23%)
LRR 2 984..1010 6/28 (21%)
leucine-rich repeat 1003..1040 CDD:275381 9/36 (25%)
leucine-rich repeat 1041..1065 CDD:275381 5/24 (21%)
LRR 3 1048..1073 8/25 (32%)
leucine-rich repeat 1066..1095 CDD:275381 8/28 (29%)
LRR 4 1074..1103 8/28 (29%)
leucine-rich repeat 1096..1120 CDD:275381 5/24 (21%)
LRR 5 1104..1128 4/24 (17%)
leucine-rich repeat 1121..1140 CDD:275381 3/18 (17%)
LRR 6 1129..1156 3/14 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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