DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and Kdm2a

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001001984.2	Gene:	Kdm2a / 225876	MGIID:	1354736	Length:	1161	Species:	Mus musculus

Alignment Length:	681	Identity:	126/681 - (18%)
Similarity:	235/681 - (34%)	Gaps:	186/681 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLITSGKPSQRREKRLFERLSCSYAQT--------------PNRMELNLNPLLAIARSIAAPPTP 54
            |.|.||  ::||..|..:..:|...:.              |.||:.:     .:.|...||..|
Mouse   558 SPIVSG--ARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQS-----CVLRQCLAPRLP 615

  Fly    55 PPTP----EKLDSDKDKEGSSKAAIE-LLPNEMWLEIMSYLSYNDLLQLRMVS-WRC-------- 105
            ....    .::|.:::.:...|..:| .:.||:.......:....||...:.: |.|
Mouse   616 HSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDS 680

  Fly   106 RDLVHRRRFMEKGKVIVTQHNLEAIHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGHE-VK 169
            .|...:|:..|..:                        |.::.:.||..|..|..|....|. ..
Mouse   681 SDKAQKRKIEESDE------------------------EAVQAKVLRPLRSCEEPLTPPPHSPTS 721

  Fly   170 HLQVRHAPVFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDAVLK 234
            .||:.|.||       .|...|...:......|.|.|:.|:.                     .|
Mouse   722 MLQLIHDPV-------SPRGMVTRSSPGAGPSDHHSASRDER---------------------FK 758

  Fly   235 MRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFE 299
            .|.||:|:.|| :..:|.     :.||.:...::  ...|.......:.:.:....|:|
Mouse   759 RRQLLRLQATE-RTMVRE-----KENNPSGKKEL--SEVEKAKIRGSYLTVTLQRPTKE------ 809

  Fly   300 NMHNLRTLKLSGNCHLVLLEAVL----------RAVPESAPIR---------------------- 332
                     |.|...:..|:|:.          |.:.:..|.|
Mouse   810 ---------LHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEEEEEE 865

  Fly   333 ----------QLDLTGMLSLTNELLLYVAGKWQSTLKVL---DLMFCVQLNAN----CIDALRQL 380
                      :|:..|..:...:........|.|..:.|   :|..|:::...    |.|  ::|
Mouse   866 DDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMRVCKTWYKWCCD--KRL 928

  Fly   381 SGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDN 445
            ..:::   ::.|:.:    :.|.|:|.|......|.|..| .:.:..:..|:.|||.|:.|.|..
Mouse   929 WTKID---LSRCKAI----VPQALSGIIKRQPVSLDLSWT-NISKKQLTWLVNRLPGLKDLLLAG 985

  Fly   446 CRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYP------ISRLRGLKELNLRG 504
            |..:.......:.|..   ||.|::.:.:.|.|..:......|..      .|:||.:.:..|.|
Mouse   986 CSWSAVSALSTSSCPL---LRTLDLRWAVGIKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAG 1047

  Fly   505 CRNVTDSSLMVGLK-LPELRALSLGYCNRLTSEGFEALT----QNCPSLEALCVSSCMAVDDETV 564
            . ::||::|.:.:: :|.|..|.|.:|:.||.:....||    ....||..|.::.|..:.|:|
Mouse  1048 L-DITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQT- 1110

  Fly   565 LNIVSNLKRLRVLNLSNCTKLTLQSIHHILA 595
            |..:..:..:.:::|..|.::|.::..|.::
Mouse  1111 LFFLRRIANVTLIDLRGCKQITRKACEHFIS 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	9/51 (18%)
		leucine-rich repeat	281..303	CDD:275381	2/21 (10%)
		LRR_RI	<297..482	CDD:238064	39/233 (17%)
		leucine-rich repeat	304..330	CDD:275381	5/35 (14%)
		leucine-rich repeat	331..357	CDD:275381	4/57 (7%)
		leucine-rich repeat	358..379	CDD:275381	5/27 (19%)
		leucine-rich repeat	384..409	CDD:275381	4/24 (17%)
		leucine-rich repeat	412..437	CDD:275381	6/24 (25%)
		AMN1	430..595	CDD:187754	43/175 (25%)
		leucine-rich repeat	438..464	CDD:275381	5/25 (20%)
		leucine-rich repeat	465..496	CDD:275381	8/36 (22%)
		leucine-rich repeat	497..521	CDD:275381	5/24 (21%)
		leucine-rich repeat	522..547	CDD:275381	8/28 (29%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	4/22 (18%)
Kdm2a	NP_001001984.2	cupin_like	199..299	CDD:389752
		JHD	304..>339	CDD:375347
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..445
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:366873	5/37 (14%)
		PHD_KDM2A	619..675	CDD:277113	9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..789		25/119 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..886		4/45 (9%)
		F-box-like	895..933	CDD:372399	8/39 (21%)
		leucine-rich repeat	929..953	CDD:275381	5/30 (17%)
		AMN1	931..1137	CDD:187754	50/218 (23%)
		leucine-rich repeat	954..977	CDD:275381	6/23 (26%)
		LRR 1	960..981		6/21 (29%)
		leucine-rich repeat	978..1001	CDD:275381	5/22 (23%)
		LRR 2	983..1009		6/28 (21%)
		leucine-rich repeat	1002..1039	CDD:275381	8/36 (22%)
		leucine-rich repeat	1040..1064	CDD:275381	5/24 (21%)
		LRR 3	1047..1072		8/25 (32%)
		leucine-rich repeat	1065..1094	CDD:275381	8/28 (29%)
		LRR 4	1073..1102		8/28 (29%)
		leucine-rich repeat	1095..1119	CDD:275381	6/24 (25%)
		LRR 5	1103..1127		5/24 (21%)
		leucine-rich repeat	1120..1139	CDD:275381	3/18 (17%)
		LRR 6	1128..1155		3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900