Protein Alignment CG12402 and FBXL13

DIOPT Version :9

• Sequence 1: NP_001303481.1
• Gene: CG12402 / 41714
• FlyBaseID: FBgn0038202
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_001381423.1
• Gene: FBXL13 / 222235
• HGNCID: 21658
• Length: 825
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 138/646 - (21%)
• Similarity: 253/646 - (39%)
• Gaps: 136/646 - (21%)

  Fly     7 TSGKPSQRREKRLFERLSCSYAQTPNRMELNLNPLLAIARSIAAPPTPPPTPEKLDSD---KDKE 68
            |:...|:::|..|..:......:..||:         |.:..||..:  ..||:..|:   .|:
Human   187 TARHKSKKKEDELILKHELQLKKWKNRL---------ILKRAAAEES--NFPERSSSEVFLVDE- 239

  Fly    69 GSSKAAIELLPNEMWLEIMSYLSYNDLLQLRMVS------------WRCRDLVHRRRFMEKGKVI 121
             :.|..|.|||....|:|..|||..|::....|:            |...|      |.....||
Human   240 -TLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAID------FSSVKNVI 297

  Fly   122 VTQHNLEAIHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGH--EVKHLQVRHAPVF----- 179
            ..::.:..:.:..      |:..|:   |.|.|.......|.|.|  .::.|.|...|.|
Human   298 PDKYIVSTLQRWR------LNVLRL---NFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESM 353

  Fly   180 RNLDGKLP-----NLKVLTIAT-TMSMDDQHLAAMDDLDM--------KQFSHL-VGFECDGVSL 229
            |::....|     ||...||.. ||.:..:|...:.:|.:        |...:| :|..|.
Human   354 RHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCH---- 414

  Fly   230 DAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDHAETLV--CVN-LFFSCSPGIDT 291
                |:..|.....|:..||    .|.:..|:...::.:..:...||.  ||. |...||
Human   415 ----KLIYLDLSGCTQISVQ----GFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCS----- 466

  Fly   292 REWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQS 356
                       .:.:|..:|..|  :.:...||: .:..:|::...|...:|:....::...:.:
Human   467 -----------RITSLVFTGAPH--ISDCTFRAL-SACKLRKIRFEGNKRVTDASFKFIDKNYPN 517

  Fly   357 TLKVLDLMFCVQLNANCIDALRQLS--GRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEE 419
                |..::..........:||.||  .:|..|.:|.|..:...||.|.|.|..:..::||:|..
Human   518 ----LSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSN 578

  Fly   420 TIFLDESSMCQLLERLPNLRRLSLDNCRQA-----------------------VTDRTMATICQY 461
            .:.|.::|:.:|.||.|||..|||.||...                       :::..:..:.::
Human   579 CVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRH 643

  Fly   462 QTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSL-MVGLKLPELRAL 525
            : :|:.|::..|.:|||.|:..:..:...      |:.|::..|..::|..: .:.:....|.:|
Human   644 K-KLKELSVSECYRITDDGIQAFCKSSLI------LEHLDVSYCSQLSDMIIKALAIYCINLTSL 701

  Fly   526 SLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLT 586
            |:..|.::|....|.|:..|..|..|.:|.|:.:.|:.:.::....|:||:|.:..||.::
Human   702 SIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNIS 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	14/53 (26%)
		leucine-rich repeat	281..303	CDD:275381	3/21 (14%)
		LRR_RI	<297..482	CDD:238064	45/209 (22%)
		leucine-rich repeat	304..330	CDD:275381	5/25 (20%)
		leucine-rich repeat	331..357	CDD:275381	3/25 (12%)
		leucine-rich repeat	358..379	CDD:275381	2/20 (10%)
		leucine-rich repeat	384..409	CDD:275381	9/24 (38%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		AMN1	430..595	CDD:187754	41/181 (23%)
		leucine-rich repeat	438..464	CDD:275381	6/48 (13%)
		leucine-rich repeat	465..496	CDD:275381	7/30 (23%)
		leucine-rich repeat	497..521	CDD:275381	4/24 (17%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	5/13 (38%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658	9/45 (20%)
		F-box-like	245..289	CDD:403981	12/43 (28%)
		leucine-rich repeat	285..312	CDD:275381	5/38 (13%)
		AMN1	312..497	CDD:187754	45/218 (21%)
		leucine-rich repeat	313..336	CDD:275381	7/25 (28%)
		leucine-rich repeat	337..362	CDD:275381	5/24 (21%)
		leucine-rich repeat	363..387	CDD:275381	7/23 (30%)
		leucine-rich repeat	388..406	CDD:275381	2/17 (12%)
		leucine-rich repeat	416..441	CDD:275381	6/28 (21%)
		leucine-rich repeat	442..491	CDD:275381	12/67 (18%)
		leucine-rich repeat	468..490	CDD:275381	5/24 (21%)
		leucine-rich repeat	492..515	CDD:275381	3/22 (14%)
		leucine-rich repeat	518..542	CDD:275381	5/23 (22%)
		AMN1	529..737	CDD:187754	52/214 (24%)
		leucine-rich repeat	543..570	CDD:275381	9/26 (35%)
		leucine-rich repeat	571..596	CDD:275381	8/24 (33%)
		leucine-rich repeat	597..645	CDD:275381	6/48 (13%)
		leucine-rich repeat	646..671	CDD:275381	7/24 (29%)
		leucine-rich repeat	672..697	CDD:275381	4/24 (17%)
		leucine-rich repeat	698..723	CDD:275381	8/24 (33%)
		leucine-rich repeat	724..749	CDD:275381	5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810