DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and AMN1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001106873.1	Gene:	AMN1 / 196394	HGNCID:	27281	Length:	258	Species:	Homo sapiens

Alignment Length:	251	Identity:	66/251 - (26%)
Similarity:	104/251 - (41%)	Gaps:	64/251 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 LQGLAGDINYSLQELHLE-ETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTR 464
            :||...|.|.| :.||.| :|:.|   ..|.    :.:...|.|.|||                :
Human    46 MQGQITDSNIS-EILHPEVQTLDL---RSCD----ISDAALLHLSNCR----------------K 86

  Fly   465 LRNLNIEYC----MKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLM-VGLKLPELRA 524
            |:.||:...    :.:|.:|:....      |....|.|.:|:.|.|:||..:: :.|....|:.
Human    87 LKKLNLNASKGNRVSVTSEGIKAVA------SSCSYLHEASLKRCCNLTDEGVVALALNCQLLKI 145

  Fly   525 LSLGYCNRLTSEGFEALTQNCPSLEALCVS-SCMAVDDETVLNIVSN--LKRLRVLNLSNCTKLT 586
            :.||.|..:|.....||.:|||.|:  ||. |...|.|..|:.:||.  .|:|..:::.:|..||
Human   146 IDLGGCLSITDVSLHALGKNCPFLQ--CVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLT 208

  Fly   587 ----------LQSIHHILAHGHNLVQLIACSIDGMDHEQAQRILES--QRPQMKQV 630
                      ...|..:|.||..|:         .||  ::.:||.  ...::|||
Human   209 DGAVEAVLTYCPQIRILLFHGCPLI---------TDH--SREVLEQLVGPNKLKQV 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	21/85 (25%)
		leucine-rich repeat	304..330	CDD:275381
		leucine-rich repeat	331..357	CDD:275381
		leucine-rich repeat	358..379	CDD:275381
		leucine-rich repeat	384..409	CDD:275381	3/7 (43%)
		leucine-rich repeat	412..437	CDD:275381	6/25 (24%)
		AMN1	430..595	CDD:187754	44/182 (24%)
		leucine-rich repeat	438..464	CDD:275381	5/25 (20%)
		leucine-rich repeat	465..496	CDD:275381	6/34 (18%)
		leucine-rich repeat	497..521	CDD:275381	8/24 (33%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	9/27 (33%)
		leucine-rich repeat	574..599	CDD:275381	8/34 (24%)
AMN1	NP_001106873.1	AMN1	37..257	CDD:187754	66/251 (26%)
		leucine-rich repeat	63..86	CDD:275381	8/45 (18%)
		leucine-rich repeat	87..116	CDD:275381	6/34 (18%)
		leucine-rich repeat	117..142	CDD:275381	8/24 (33%)
		leucine-rich repeat	143..168	CDD:275381	9/24 (38%)
		leucine-rich repeat	169..195	CDD:275381	9/27 (33%)
		leucine-rich repeat	196..221	CDD:275381	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900