Protein Alignment CG12402 and B0564.6

DIOPT Version :10

• Sequence 1: NP_001303481.1
• Gene: CG12402 / 41714
• FlyBaseID: FBgn0038202
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_502527.1
• Gene: B0564.6 / 182046
• WormBaseID: WBGene00007206
• Length: 423
• Species: Caenorhabditis elegans
• Alignment Length: 542
• Identity: 115/542 - (21%)
• Similarity: 196/542 - (36%)
• Gaps: 182/542 - (33%)

  Fly    80 NEMWLEIMSYLSYNDLLQLRMVSWRCRDLVHRRRFMEKGKVIVTQHNLEAIHKHAKGGNCYLSFE 144
            ::.||||:..|:..|.::||..|.:..:||.:
 Worm     2 DQAWLEIIDRLTIEDAIRLRRTSSKVDNLVSK--------------------------------- 33

  Fly   145 RIELRNLRQCRQLENFLRLVGHEVKHLQVR-HAP-VFRNLDGKLPNLKVLTIATTMSMDDQHLAA 207
              .|:::|                 ||.|: |.| |.|:      ::.:.::....|.:
 Worm    34 --SLKSMR-----------------HLDVQMHCPSVIRD------SVAMASVIAQCSYN------ 67

  Fly   208 MDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENAL--LDVLQ 270
            :..||:|..|....:.  |:..|..::..::..:  .||..:||.|..:..|.:..|:  ...|.
 Worm    68 LQTLDLKIRSDNAKYA--GIPSDVKIRRNVMTSI--NENATKLRKLHIDRCRISPGAIGSFGDLP 128

  Fly   271 DHAETLVCVNLFFSCSPGIDTREW----------------CRAFENMHNLRTLKLSGNC----HL 315
            |..|.:...|....||      ||                ||      .||..::||.|    |.
 Worm   129 DSIEEISITNSMIECS------EWDVATIIRKSFGTLLKKCR------KLRYFEISGQCLMNSHF 181

  Fly   316 VLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLM--FCVQLNANCIDALR 378
            .:...:|:.:  |..:..|.:....|||...|.::..|   .||.|:|.  |....:...|.|:.
 Worm   182 HVDPKILQFI--SNTVEHLAIAVGHSLTINSLAFLKDK---RLKTLNLQRSFISPCDLEHIVAMA 241

  Fly   379 QLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSL 443
            .....|:                  |:..:|            .||    |:.:..|.|||.|||
 Worm   242 DTITHLD------------------LSRSVN------------LLD----CRQIAELVNLRHLSL 272

  Fly   444 DNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNV 508
            .|.::.|.|.::..|.:..::|..|:::.|..:|...|:..|:       |..||:|:|.|..||
 Worm   273 KNNKEGVRDDSLQLIIKNCSKLEELSLDCCEYLTVNSLITLGN-------LNNLKQLSLPGIVNV 330

  Fly   509 TDSSLMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKR 573
            .||..:...:..:|..|::.:|.|:...|.            ||:.||:           ::|..
 Worm   331 DDSVCLQISRCSKLTYLNINFCRRVQKRGL------------LCLLSCL-----------TSLDH 372

  Fly   574 LRVLNLSNCTKLTLQSIHHILA 595
            |.||.:...:       ||:||
 Worm   373 LEVLGIRAYS-------HHLLA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:425796	11/36 (31%)
		leucine-rich repeat	281..303	CDD:275381	6/37 (16%)
		PPP1R42	<297..482	CDD:455733	42/190 (22%)
		leucine-rich repeat	304..330	CDD:275381	8/29 (28%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/22 (32%)
		leucine-rich repeat	384..409	CDD:275381	2/24 (8%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	42/164 (26%)
		leucine-rich repeat	438..464	CDD:275381	9/25 (36%)
		leucine-rich repeat	465..496	CDD:275381	7/30 (23%)
		leucine-rich repeat	497..521	CDD:275381	9/23 (39%)
		leucine-rich repeat	522..547	CDD:275381	5/24 (21%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	7/22 (32%)
B0564.6	NP_502527.1	leucine-rich repeat	106..130	CDD:275381	6/23 (26%)
		leucine-rich repeat	131..159	CDD:275381	6/33 (18%)
		leucine-rich repeat	166..193	CDD:275381	7/28 (25%)
		leucine-rich repeat	195..214	CDD:275381	5/18 (28%)
		LRR	<209..>353	CDD:443914	44/187 (24%)
		leucine-rich repeat	219..243	CDD:275381	7/23 (30%)
		leucine-rich repeat	244..266	CDD:275381	7/55 (13%)
		leucine-rich repeat	267..293	CDD:275381	9/25 (36%)
		leucine-rich repeat	294..318	CDD:275381	7/30 (23%)
		leucine-rich repeat	319..343	CDD:275381	9/23 (39%)