DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and B0564.9

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_502528.2	Gene:	B0564.9 / 178266	WormBaseID:	WBGene00007208	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	115/542 - (21%)
Similarity:	196/542 - (36%)	Gaps:	182/542 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NEMWLEIMSYLSYNDLLQLRMVSWRCRDLVHRRRFMEKGKVIVTQHNLEAIHKHAKGGNCYLSFE 144
            ::.||||:..|:..|.::||..|.:..:||.:
Worm     2 DQAWLEIIDRLTIEDAIRLRRTSSKVDNLVSK--------------------------------- 33

  Fly   145 RIELRNLRQCRQLENFLRLVGHEVKHLQVR-HAP-VFRNLDGKLPNLKVLTIATTMSMDDQHLAA 207
              .|:::|                 ||.|: |.| |.|:      ::.:.::....|.:
Worm    34 --SLKSMR-----------------HLDVQMHCPSVIRD------SVAMASVIAQCSYN------ 67

  Fly   208 MDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENAL--LDVLQ 270
            :..||:|..|....:.  |:..|..::..::..:  .||..:||.|..:..|.:..|:  ...|.
Worm    68 LQTLDLKIRSDNAKYA--GIPSDVKIRRNVMTSI--NENATKLRKLHIDRCRISPGAIGSFGDLP 128

  Fly   271 DHAETLVCVNLFFSCSPGIDTREW----------------CRAFENMHNLRTLKLSGNC----HL 315
            |..|.:...|....||      ||                ||      .||..::||.|    |.
Worm   129 DSIEEISITNSMIECS------EWDVATIIRKSFGTLLKKCR------KLRYFEISGQCLMNSHF 181

  Fly   316 VLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLM--FCVQLNANCIDALR 378
            .:...:|:.:  |..:..|.:....|||...|.::..|   .||.|:|.  |....:...|.|:.
Worm   182 HVDPKILQFI--SNTVEHLAIAVGHSLTINSLAFLKDK---RLKTLNLQRSFISPCDLEHIVAMA 241

  Fly   379 QLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSL 443
            .....|:                  |:..:|            .||    |:.:..|.|||.|||
Worm   242 DTITHLD------------------LSRSVN------------LLD----CRQIAELVNLRHLSL 272

  Fly   444 DNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNV 508
            .|.::.|.|.::..|.:..::|..|:::.|..:|...|:..|:       |..||:|:|.|..||
Worm   273 KNNKEGVRDDSLQLIIKNCSKLEELSLDCCEYLTVNSLITLGN-------LNNLKQLSLPGIVNV 330

  Fly   509 TDSSLMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKR 573
            .||..:...:..:|..|::.:|.|:...|.            ||:.||:           ::|..
Worm   331 DDSVCLQISRCSKLTYLNINFCRRVQKRGL------------LCLLSCL-----------TSLDH 372

  Fly   574 LRVLNLSNCTKLTLQSIHHILA 595
            |.||.:...:       ||:||
Worm   373 LEVLGIRAYS-------HHLLA 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	11/36 (31%)
		leucine-rich repeat	281..303	CDD:275381	6/37 (16%)
		LRR_RI	<297..482	CDD:238064	42/190 (22%)
		leucine-rich repeat	304..330	CDD:275381	8/29 (28%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/22 (32%)
		leucine-rich repeat	384..409	CDD:275381	2/24 (8%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	42/164 (26%)
		leucine-rich repeat	438..464	CDD:275381	9/25 (36%)
		leucine-rich repeat	465..496	CDD:275381	7/30 (23%)
		leucine-rich repeat	497..521	CDD:275381	9/23 (39%)
		leucine-rich repeat	522..547	CDD:275381	5/24 (21%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	7/22 (32%)
B0564.9	NP_502528.2	leucine-rich repeat	106..130	CDD:275381	6/23 (26%)
		leucine-rich repeat	131..159	CDD:275381	6/33 (18%)
		leucine-rich repeat	166..193	CDD:275381	7/28 (25%)
		leucine-rich repeat	195..214	CDD:275381	5/18 (28%)
		leucine-rich repeat	219..243	CDD:275381	7/23 (30%)
		leucine-rich repeat	244..266	CDD:275381	7/55 (13%)
		leucine-rich repeat	267..293	CDD:275381	9/25 (36%)
		leucine-rich repeat	294..318	CDD:275381	7/30 (23%)
		leucine-rich repeat	319..343	CDD:275381	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I6911
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I3993
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17020
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.980