DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and EEED8.10

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001040757.1	Gene:	EEED8.10 / 173919	WormBaseID:	WBGene00017138	Length:	738	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	102/437 - (23%)
Similarity:	172/437 - (39%)	Gaps:	131/437 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 LEAVL-RAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLMFCVQLNANC-------- 373
            |:|:| ||   .|.:|.||::|::.|.::         :..|||:         |.|
Worm   305 LKAILTRA---GAHLRSLDVSGIVHLLDD---------RRALKVI---------ATCCPNLVDLD 348

  Fly   374 -------IDALRQLSGRLEALTMAYCRELTGTG------LLQGLAGDINY--------------- 410
                   .:||.:|...|..|.....|.:..||      ||:.....:.:
Worm   349 ISGTHAQAEALEELGESLSHLEQLSYRGMETTGDKAFYFLLKNCGHSLKFVDLRNSKRLHGRSFK 413

  Fly   411 ----SLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNI- 470
                .|:.|:|:.:..:||.:...|......|:.|.::.|.: :||..::.|.:   |:.:|:|
Worm   414 LFGSQLESLYLDGSSKVDEMAFEDLCTSCGGLKELRINECYK-ITDENLSMIAR---RMEDLSIL 474

  Fly   471 EYC----MKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLM-VGLKLPELRALSL--- 527
            ..|    ..:|..||:       .||.:|.:.||.|.....|.|..|: :...||.|.:|||
Worm   475 TLCGDGFKSLTSAGLI-------HISHMRNITELALDYNALVNDELLISISAGLPLLSSLSLANA 532

  Fly   528 GYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCT--------- 583
            |..:.:|:||..|: :|...|..|..||..||:.: ||..:.:||:|.::.|.|||
Worm   533 GNDSSITAEGVSAI-KNLKELTQLDASSLAAVNSK-VLEQLGSLKKLEIIQLRNCTYLGDDGVRA 595

  Fly   584 KLTLQSIHHILAHGHNLVQLIACSIDGMDHEQAQRILES--QRPQMKQVLL------XQERYIHX 640
            ||.:.:|.|:...|..||          .::..|:.:::  ..|::..:.|      .....:..
Worm   596 KLRMPNIRHVDLSGSILV----------SNDSIQQFIKAFPSGPKLPPITLVVGGTAADASKLSV 650

  Fly   641 R-SRNTPHHNDW-------------------GNHEDDEFDDDETEII 667
            | ||.....:|:                   |:..|.|..|||.|.:
Worm   651 RGSRVVVDFSDYSTIVTMQTSQCSSSKFAIGGSASDAEGSDDEFEAL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	44/209 (21%)
		leucine-rich repeat	304..330	CDD:275381	5/12 (42%)
		leucine-rich repeat	331..357	CDD:275381	5/25 (20%)
		leucine-rich repeat	358..379	CDD:275381	7/35 (20%)
		leucine-rich repeat	384..409	CDD:275381	7/30 (23%)
		leucine-rich repeat	412..437	CDD:275381	6/24 (25%)
		AMN1	430..595	CDD:187754	54/182 (30%)
		leucine-rich repeat	438..464	CDD:275381	6/25 (24%)
		leucine-rich repeat	465..496	CDD:275381	8/35 (23%)
		leucine-rich repeat	497..521	CDD:275381	7/24 (29%)
		leucine-rich repeat	522..547	CDD:275381	10/27 (37%)
		leucine-rich repeat	548..573	CDD:275381	9/24 (38%)
		leucine-rich repeat	574..599	CDD:275381	10/33 (30%)
EEED8.10	NP_001040757.1	RRM	<101..273	CDD:223796
		RRM_SF	114..197	CDD:240668
		AMN1	<313..>464	CDD:187754	32/169 (19%)
		leucine-rich repeat	316..337	CDD:275381	7/29 (24%)
		leucine-rich repeat	344..368	CDD:275381	4/23 (17%)
		leucine-rich repeat	369..395	CDD:275381	6/25 (24%)
		AMN1	394..615	CDD:187754	62/243 (26%)
		leucine-rich repeat	396..418	CDD:275381	0/21 (0%)
		leucine-rich repeat	419..444	CDD:275381	6/24 (25%)
		leucine-rich repeat	445..470	CDD:275381	7/28 (25%)
		leucine-rich repeat	471..497	CDD:275381	8/32 (25%)
		leucine-rich repeat	498..520	CDD:275381	6/21 (29%)
		leucine-rich repeat	524..551	CDD:275381	10/27 (37%)
		leucine-rich repeat	552..576	CDD:275381	9/24 (38%)
		leucine-rich repeat	577..601	CDD:275381	7/23 (30%)
		leucine-rich repeat	602..627	CDD:275381	6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030