DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12402 and FBXL16

DIOPT Version :9

Sequence 1:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster
Sequence 2:NP_699181.2 Gene:FBXL16 / 146330 HGNCID:14150 Length:479 Species:Homo sapiens


Alignment Length:239 Identity:72/239 - (30%)
Similarity:113/239 - (47%) Gaps:25/239 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   377 LRQLSG--RLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLR 439
            |.|:.|  |||   ::.|.:.|..||...|:..|.    .|.:.:.|.:.:.::..:.:.||||.
Human   214 LEQMQGVVRLE---LSGCNDFTEAGLWSSLSARIT----SLSVSDCINVADDAIAAISQLLPNLA 271

  Fly   440 RLSLDNCRQA--VTDRTMATICQYQTR-LRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELN 501
            .|||    ||  |||..:|.....|.. ...|.:..|.:||:.|::..      :..|..|..|:
Human   272 ELSL----QAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNV------VHSLPNLTALS 326

  Fly   502 LRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVL 565
            |.||..|||..: :|...|.:||:|.|.:|.|:|....|.:..:...||.|.:..|:.:.| |.|
Human   327 LSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITD-TGL 390

  Fly   566 NIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGH-NLVQLIACSI 608
            :.:|.:..||.|.|..|.::....:.|:||.|. .|:.|..|.:
Human   391 SYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPL 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12402NP_001303481.1 F-box 75..117 CDD:279040
leucine-rich repeat 281..303 CDD:275381
LRR_RI <297..482 CDD:238064 33/109 (30%)
leucine-rich repeat 304..330 CDD:275381
leucine-rich repeat 331..357 CDD:275381
leucine-rich repeat 358..379 CDD:275381 1/1 (100%)
leucine-rich repeat 384..409 CDD:275381 7/24 (29%)
leucine-rich repeat 412..437 CDD:275381 3/24 (13%)
AMN1 430..595 CDD:187754 52/168 (31%)
leucine-rich repeat 438..464 CDD:275381 11/27 (41%)
leucine-rich repeat 465..496 CDD:275381 6/30 (20%)
leucine-rich repeat 497..521 CDD:275381 10/24 (42%)
leucine-rich repeat 522..547 CDD:275381 8/24 (33%)
leucine-rich repeat 548..573 CDD:275381 8/24 (33%)
leucine-rich repeat 574..599 CDD:275381 9/25 (36%)
FBXL16NP_699181.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
AMN1 201..413 CDD:332986 65/216 (30%)
leucine-rich repeat 220..243 CDD:275381 8/25 (32%)
leucine-rich repeat 244..269 CDD:275381 4/28 (14%)
LRR 1 244..266 3/25 (12%)
LRR 2 267..290 13/26 (50%)
leucine-rich repeat 270..295 CDD:275381 11/28 (39%)
leucine-rich repeat 296..321 CDD:275381 6/30 (20%)
LRR 3 319..343 10/23 (43%)
leucine-rich repeat 322..347 CDD:275381 10/24 (42%)
LRR 4 345..369 9/23 (39%)
leucine-rich repeat 348..373 CDD:275381 8/24 (33%)
LRR 5 371..395 7/24 (29%)
leucine-rich repeat 374..398 CDD:275381 8/24 (33%)
LRR 6 396..420 6/23 (26%)
LRR 7 446..470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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