DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and FBXL14

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_689654.1	Gene:	FBXL14 / 144699	HGNCID:	28624	Length:	418	Species:	Homo sapiens

Alignment Length:	307	Identity:	84/307 - (27%)
Similarity:	147/307 - (47%)	Gaps:	29/307 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 LVLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQ 379
            |.|..::...:...|.|..|:|:|..:||:..|.:...:...:|:.|:|..|.|:..:.:..:.|
Human    76 LSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQ 140

  Fly   380 LSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQEL---------HLEETIFLDESSMCQ-LLER 434
            ....||.|.:..|..:|.||||.     |.:.||.|         ||.:......:.|.: ..|.
Human   141 YLKGLEVLELGGCSNITNTGLLL-----IAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEG 200

  Fly   435 LPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKE 499
            ...|.:|:|.:| |.:||.::..|.:..|.||.||:.:|..|:|.||:       .:|.:..|:.
Human   201 CLGLEQLTLQDC-QKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLL-------HLSHMGSLRS 257

  Fly   500 LNLRGCRNVTDSSLMVGLKLPELR--ALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDE 562
            ||||.|.|::|:.:| .|.:..||  .|.:.:|:::..:....:.|....|::|.:.|| .:.|:
Human   258 LNLRSCDNISDTGIM-HLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDD 320

  Fly   563 TVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNL--VQLIACS 607
            .:..:|..:..||.||:..|.::|.:.:..|..|...|  :.|..|:
Human   321 GINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCT 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	50/176 (28%)
		leucine-rich repeat	304..330	CDD:275381	2/14 (14%)
		leucine-rich repeat	331..357	CDD:275381	7/25 (28%)
		leucine-rich repeat	358..379	CDD:275381	5/20 (25%)
		leucine-rich repeat	384..409	CDD:275381	9/24 (38%)
		leucine-rich repeat	412..437	CDD:275381	7/34 (21%)
		AMN1	430..595	CDD:187754	48/167 (29%)
		leucine-rich repeat	438..464	CDD:275381	8/25 (32%)
		leucine-rich repeat	465..496	CDD:275381	10/30 (33%)
		leucine-rich repeat	497..521	CDD:275381	10/23 (43%)
		leucine-rich repeat	522..547	CDD:275381	5/26 (19%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	8/24 (33%)
FBXL14	NP_689654.1	Required for down-regulation of SNAI1	2..48
		F-box-like	5..46	CDD:403981
		AMN1	90..296	CDD:187754	64/219 (29%)
		leucine-rich repeat	92..118	CDD:275381	7/25 (28%)
		leucine-rich repeat	119..142	CDD:275381	6/22 (27%)
		LRR 1	144..163		8/18 (44%)
		leucine-rich repeat	145..170	CDD:275381	11/29 (38%)
		LRR 2	170..191		3/20 (15%)
		leucine-rich repeat	171..203	CDD:275381	5/31 (16%)
		LRR 3	203..225		8/22 (36%)
		leucine-rich repeat	204..229	CDD:275381	8/25 (32%)
		AMN1	228..401	CDD:187754	43/149 (29%)
		LRR 4	229..250		9/27 (33%)
		leucine-rich repeat	230..254	CDD:275381	10/30 (33%)
		LRR 5	254..275		9/21 (43%)
		leucine-rich repeat	255..280	CDD:275381	10/25 (40%)
		leucine-rich repeat	281..306	CDD:275381	3/24 (13%)
		leucine-rich repeat	307..331	CDD:275381	6/24 (25%)
		leucine-rich repeat	332..357	CDD:275381	8/24 (33%)
		leucine-rich repeat	358..382	CDD:275381	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810