DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and fbxl4

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_031761765.1	Gene:	fbxl4 / 100490265	XenbaseID:	XB-GENE-961513	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	117/533 - (21%)
Similarity:	198/533 - (37%)	Gaps:	130/533 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 HNLEAIHKH------AKGGNCYLSFERIELR------------NLRQCRQLENFLRLVGHEVKHL 171
            |.||..|..      |...|.|......|:|            |..|.||....|:.:......|
Frog   143 HILETYHPGSVVKILACSANPYSQSAPAEIRWETIWSGEPTRVNSPQSRQFTPCLKEISFPTNLL 207

  Fly   172 QVRH----APVFRNLDG-------KLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECD 225
            ::..    ...:..||.       :.|.|.:.|.|..||..|      ||.|.|          |
Frog   208 RLETNSSLLDYYTELDAVELHGVKEKPVLFLKTAAIDMSDLD------DDYDDK----------D 256

  Fly   226 GVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDH---------AETLVCVNL 281
            ...||::........:|...|......|.:|        |:..:..|         |:|  |..:
Frog   257 SCELDSLTNQLSNTGIREWTNNGYFDKLPYE--------LIQFIISHLALPDLCRLAQT--CKLM 311

  Fly   282 FFSCSPGIDTREWCRAFENMHNLRTLKLS---GNCHLVLLEAVLRAVPESAPIRQLDLT-----G 338
            :..|         |...:..|    |.|.   .|.:...||.:|   |..:.::.|:|:     |
Frog   312 YQHC---------CDPLQYTH----LSLQPYWTNVNDNSLEYLL---PRCSLVQWLNLSWTGNRG 360

  Fly   339 MLSLTN-ELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGL-- 400
            ::|.:. ..||.|.|   |.|..|:|.....||..|::.:.::...|:.|.::.|.:|.....
Frog   361 LISTSGFSRLLKVCG---SELVRLELACGHFLNEACLEVIAEMCPNLQELNLSSCDKLPPQAFSH 422

  Fly   401 ---LQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATI---- 458
               |.||...:.|..:   :|:|..|...:.|      |.::.|:|.:|........:|::
Frog   423 ICKLSGLKRLVLYRTK---IEQTALLSILNFC------PEIQHLNLGSCVLIEDYDLVASVLGAK 478

  Fly   459 CQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRG----LKELNLRGCRNVTDSS---LMVG 516
            |:   :||:|::..|..||::|          |:.|..    |:||:|..|..:..|:   :.:.
Frog   479 CK---KLRSLDLWRCKNITERG----------IAELASGCLLLEELDLGWCPTLQSSTGCFVNLA 530

  Fly   517 LKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSN 581
            .|||.||.|.|.....:.....|.|.:||..|:.|.:.....|....:..::...|.|.:|::|.
Frog   531 SKLPNLRKLFLTANRSVCDSDIEELARNCQHLQQLDILGTRMVSPAALCKLLECCKELFLLDVSF 595

  Fly   582 CTKLTLQSIHHIL 594
            |:::..:.:..::
Frog   596 CSQIDSRVVQELV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	2/21 (10%)
		LRR_RI	<297..482	CDD:238064	48/202 (24%)
		leucine-rich repeat	304..330	CDD:275381	7/28 (25%)
		leucine-rich repeat	331..357	CDD:275381	8/31 (26%)
		leucine-rich repeat	358..379	CDD:275381	6/20 (30%)
		leucine-rich repeat	384..409	CDD:275381	7/29 (24%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	40/176 (23%)
		leucine-rich repeat	438..464	CDD:275381	5/29 (17%)
		leucine-rich repeat	465..496	CDD:275381	9/30 (30%)
		leucine-rich repeat	497..521	CDD:275381	8/26 (31%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	3/24 (13%)
		leucine-rich repeat	574..599	CDD:275381	4/21 (19%)
fbxl4	XP_031761765.1	F-box-like	281..325	CDD:403981	10/66 (15%)
		leucine-rich repeat	296..318	CDD:275381	5/32 (16%)
		leucine-rich repeat	319..341	CDD:275381	6/25 (24%)
		leucine-rich repeat	348..377	CDD:275381	8/31 (26%)
		leucine-rich repeat	378..403	CDD:275381	6/24 (25%)
		leucine-rich repeat	404..428	CDD:275381	5/23 (22%)
		AMN1	427..606	CDD:187754	47/200 (24%)
		leucine-rich repeat	429..453	CDD:275381	6/32 (19%)
		leucine-rich repeat	454..481	CDD:275381	5/29 (17%)
		leucine-rich repeat	482..507	CDD:275381	9/34 (26%)
		leucine-rich repeat	508..535	CDD:275381	8/26 (31%)
		leucine-rich repeat	536..561	CDD:275381	8/24 (33%)
		leucine-rich repeat	562..587	CDD:275381	3/24 (13%)
		leucine-rich repeat	588..613	CDD:275381	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910