DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and si:ch73-173p19.1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_002660968.3	Gene:	si:ch73-173p19.1 / 100332407	ZFINID:	ZDB-GENE-130530-952	Length:	918	Species:	Danio rerio

Alignment Length:	773	Identity:	164/773 - (21%)
Similarity:	285/773 - (36%)	Gaps:	221/773 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KRLFE-RLSCSYAQTPNRMELNLNPLLAIARSIAAPPTP--PPTP-------EKLDSDKDKEGSS 71
            ||..| .|:||.      ..|.|.|..|:......|.||  ||:|       |:.:::..:|..:
Zfish   235 KRFGETELTCSL------RSLGLTPNAALCIQTTPPETPQDPPSPAPRLAVVEQPEAEPQEEPIA 293

  Fly    72 KAAIEL-----------LPNEMWLEIMSYLSYNDL------------LQLRMVSWRCRDLVHRRR 113
            ...:|.           ||:::|.|.:.|.....:            ...::|.....|..|...
Zfish   294 PPQVEAGALEEQEVPPPLPHQLWEEAVGYAGIPGVGPPLSGPSHFWGRGQKLVQGDAEDEEHLEN 358

  Fly   114 FMEKGKVIVTQHNLEAI-------HKHAKGGNCYLSFERIELRN--------LRQCR-------- 155
            ..::.:.:|...|.|.:       ...|:||        ::||:        ||:..
Zfish   359 EEQQEEEVVPPFNFEGLPRLPFFMENRARGG--------LDLRHHWPEQGNRLREVEPDDPADPD 415

  Fly   156 ------------QLENFLRLVGHEVKH-LQVRHAP---VFRNLDGKLPNLKVLTIATTMSMDDQH 204
                        .:|...|...|:.:| ...:.:|   .|:.  .::|:|..:....|:|:
Zfish   416 EGRALRGAAGQAAVERLQRGAHHDEQHSTHGQPSPPKKPFKT--PRVPSLCSMATRATVSL---- 474

  Fly   205 LAAMDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVL 269
               |....|:..|.|.   |    |...|...:|..:.| |..::.|.|:
Zfish   475 ---MTAPSMQYSSSLA---C----LTPELAELLLSHMAR-ERLLRPRTLE--------------- 513

  Fly   270 QDHAETLVCVNLFFSCSPGIDTREW---CRAFENMHNLRTLKLSGNC--HL------VLLEAVLR 323
                       |||.|    ..:::   |..:.....||.|: :..|  ||      ::.:|.|.
Zfish   514 -----------LFFGC----PLQKFVLNCYPYTTNELLRQLR-AFTCLKHLSFLNSPLITDAGLS 562

  Fly   324 AVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLD--------LMFCVQLNANCIDALRQL 380
            .:...:.::.|:|:....||:..|.::.|....|...||        |:..:|..::   ||.||
Zfish   563 VLSNLSKLQHLNLSSCSKLTDSCLQHITGLRSLTFLALDQTKVSDAGLLLYLQSGSS---ALCQL 624

  Fly   381 SGRLEALTMAYCRELTGT-------GLLQGLAGDIN-----YSLQELHLEETIFLDESSMCQLLE 433
            |....|:|.:..|.|..:       .:......|::     .:||.|||:.|...:.|..|  |.
Zfish   625 SLNQTAITESTLRVLPASVPQLRMLSIKHTKVSDVSALAELKNLQTLHLDGTGVQENSLQC--LA 687

  Fly   434 RLPNLRRLSLDNC------------------------RQAVTDRTMATICQYQTRLRNLNIEYCM 474
            ..|:|..|||...                        |.:|||..::.:.: ||.|..|::....
Zfish   688 SHPSLSALSLAGIPVADGNHTLEIIAGLRLTQLTLPGRHSVTDSGLSFLSR-QTLLLELDLTDYT 751

  Fly   475 KITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLMVGLKLPELRALSLGYCNRLTSEGFE 539
            ::||.|:.       .:|.:..||:|:|...: |:||.|...::|.||:.|.|.. ..:||.|..
Zfish   752 QLTDHGIT-------QLSSMTRLKKLSLSNTQ-VSDSGLQGLIRLKELQELCLDR-TAVTSRGVA 807

  Fly   540 ALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQLI 604
            ||..:.|.|:.:.::|.. |.|..:...:.:..:|..||||. |::|.|.:..:..     :||.
Zfish   808 ALITHLPHLQVMGLASTQ-VGDTVIRRGLVHCPQLLKLNLSR-TRITDQGLKFLCR-----MQLS 865

  Fly   605 ACSIDGMDHEQAQ-RILESQRPQMKQVLLXQERYIHXRSRNTPHHNDWGNHEDDEFDD 661
            ..::||....... ..|.|..|.:..|     |..|.|:......:|    :||::::
Zfish   866 QVNLDGTGVTLVGIANLISACPHLSSV-----RASHTRAIPPDQQSD----DDDDYNN 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	9/64 (14%)
		leucine-rich repeat	281..303	CDD:275381	5/24 (21%)
		LRR_RI	<297..482	CDD:238064	54/236 (23%)
		leucine-rich repeat	304..330	CDD:275381	8/33 (24%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	6/28 (21%)
		leucine-rich repeat	384..409	CDD:275381	5/31 (16%)
		leucine-rich repeat	412..437	CDD:275381	9/24 (38%)
		AMN1	430..595	CDD:187754	49/188 (26%)
		leucine-rich repeat	438..464	CDD:275381	9/49 (18%)
		leucine-rich repeat	465..496	CDD:275381	6/30 (20%)
		leucine-rich repeat	497..521	CDD:275381	9/23 (39%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	4/24 (17%)
		leucine-rich repeat	574..599	CDD:275381	8/24 (33%)
si:ch73-173p19.1	XP_002660968.3	UBA_like_SF	6..43	CDD:304366
		Nop25	116..>169	CDD:286843
		UBQ	187..260	CDD:294102	10/30 (33%)
		AMN1	523..701	CDD:187754	44/183 (24%)
		LRR	<524..710	CDD:227223	44/191 (23%)
		leucine-rich repeat	545..569	CDD:275381	4/23 (17%)
		leucine-rich repeat	570..594	CDD:275381	6/23 (26%)
		leucine-rich repeat	595..620	CDD:275381	5/27 (19%)
		leucine-rich repeat	621..645	CDD:275381	8/23 (35%)
		leucine-rich repeat	646..691	CDD:275381	10/46 (22%)
		leucine-rich repeat	692..766	CDD:275381	16/81 (20%)
		leucine-rich repeat	717..742	CDD:275381	6/25 (24%)
		AMN1	750..>888	CDD:187754	41/153 (27%)
		leucine-rich repeat	767..790	CDD:275381	9/23 (39%)
		leucine-rich repeat	791..815	CDD:275381	8/24 (33%)
		leucine-rich repeat	816..840	CDD:275381	4/24 (17%)
		leucine-rich repeat	841..863	CDD:275381	8/27 (30%)
		leucine-rich repeat	864..888	CDD:275381	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900