DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and fbxl16

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001096414.1	Gene:	fbxl16 / 100125019	XenbaseID:	XB-GENE-5821642	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	239	Identity:	72/239 - (30%)
Similarity:	110/239 - (46%)	Gaps:	25/239 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 LRQLSG--RLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLR 439
            |.|:.|  |||   ::.|.:.|..||...|.|.|.    .|.:.:.|.:.:.::..:.:.||||.
Frog   232 LEQMQGVVRLE---LSGCNDFTEAGLWSSLHGRIT----SLSVSDCINVADDAVAAISQLLPNLG 289

  Fly   440 RLSLDNCRQA--VTDRTMATICQYQTR-LRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELN 501
            .|:|    ||  |||..:|.....|.| ...|.:..|.:||:.|::..      :..|..|..|:
Frog   290 ELNL----QAYHVTDTALAYFTAKQGRATHTLRLHSCWEITNHGVVNV------VHSLPNLTVLS 344

  Fly   502 LRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVL 565
            |.||..|||..: :|...|..||.|.|.:|.|||....|.:..:...||.|.:..|:.:.| |.|
Frog   345 LSGCSKVTDDGVELVAENLRRLRGLDLSWCPRLTDTALEYIACDLHKLEELVLDRCVRITD-TGL 408

  Fly   566 NIVSNLKRLRVLNLSNCTKLTLQSIHHILA-HGHNLVQLIACSI 608
            :.:|.:..|..|.|..|.::....:.|:|| ....|:.|..|.:
Frog   409 SYLSTMPSLHSLYLRWCCQVQDFGLKHLLAMKSLRLLSLAGCPL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	34/109 (31%)
		leucine-rich repeat	304..330	CDD:275381
		leucine-rich repeat	331..357	CDD:275381
		leucine-rich repeat	358..379	CDD:275381	1/1 (100%)
		leucine-rich repeat	384..409	CDD:275381	8/24 (33%)
		leucine-rich repeat	412..437	CDD:275381	3/24 (13%)
		AMN1	430..595	CDD:187754	52/168 (31%)
		leucine-rich repeat	438..464	CDD:275381	10/27 (37%)
		leucine-rich repeat	465..496	CDD:275381	6/30 (20%)
		leucine-rich repeat	497..521	CDD:275381	10/24 (42%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	8/24 (33%)
		leucine-rich repeat	574..599	CDD:275381	7/25 (28%)
fbxl16	NP_001096414.1	F-box	113..152	CDD:306992
		AMN1	<222..353	CDD:332986	41/137 (30%)
		leucine-rich repeat	238..261	CDD:275381	8/25 (32%)
		leucine-rich repeat	262..287	CDD:275381	4/28 (14%)
		leucine-rich repeat	288..313	CDD:275381	10/28 (36%)
		AMN1	297..476	CDD:332986	49/163 (30%)
		leucine-rich repeat	314..339	CDD:275381	6/30 (20%)
		leucine-rich repeat	340..365	CDD:275381	10/24 (42%)
		leucine-rich repeat	366..391	CDD:275381	9/24 (38%)
		leucine-rich repeat	392..416	CDD:275381	8/24 (33%)
		leucine-rich repeat	417..436	CDD:275381	4/18 (22%)
		leucine-rich repeat	442..466	CDD:275381	3/11 (27%)
		leucine-rich repeat	467..492	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910