DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK1-R and Ghsr

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_114464.1	Gene:	Ghsr / 84022	RGDID:	621397	Length:	364	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	123/411 - (29%)
Similarity:	187/411 - (45%)	Gaps:	90/411 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NMSHDLGPPRD----------PLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYL 59
            ::..|..|..|          |..::..||.....:|:.|:.||:.|.:|:.:.|.:.|.||.||
  Rat    17 DLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYL 81

  Fly    60 FSLAISDFLLLLSGVPQEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAIC 124
            .|:|.||.|:.|. :|.::..:|...|:.||:.:|.....::|:...||||||||.:||||.|||
  Rat    82 SSMAFSDLLIFLC-MPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAIC 145

  Fly   125 HPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYSGVE-----QC---------GIVR 175
            .|...:.:....|...:|:::|.:|..:|.|.....|:||.:|.:     :|         |::.
  Rat   146 FPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLT 210

  Fly   176 VIVKHSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGG 240
            |:|..|     .:||..|:..:.|||.|||..|:|           ||
  Rat   211 VMVWVS-----SVFFFLPVFCLTVLYSLIGRKLWR-----------RR----------------- 242

  Fly   241 SGTAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRL 305
                                 |..|..:|:|.: ||   ::.::||..||..|.|||.|||..|.
  Rat   243 ---------------------GDAAVGASLRDQ-NH---KQTVKMLAVVVFAFILCWLPFHVGRY 282

  Fly   306 IAIYAPARGAKLRDQHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFGKKVSKG 370
            :...:...|:....|   :......||.||:|||..|||:||||||.|:|.|...:|..:..|:.
  Rat   283 LFSKSFEPGSLEIAQ---ISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQR 344

  Fly   371 SLNSRNNIESRRLRRALTNSS 391
            .|::..:..|    ||.|.||
  Rat   345 KLSTLKDESS----RAWTKSS 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	109/350 (31%)
		TM helix 1	21..48	CDD:320262	8/26 (31%)
		TM helix 2	55..81	CDD:320262	11/25 (44%)
		TM helix 3	94..124	CDD:320262	15/29 (52%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	11/28 (39%)
		TM helix 6	277..307	CDD:320262	12/29 (41%)
		TM helix 7	326..351	CDD:320262	14/24 (58%)
Ghsr	NP_114464.1	7tmA_GHSR	44..332	CDD:320259	109/349 (31%)
		TM helix 1	45..69	CDD:320259	8/23 (35%)
		TM helix 2	78..99	CDD:320259	10/21 (48%)
		TM helix 3	116..138	CDD:320259	9/21 (43%)
		TM helix 4	161..177	CDD:320259	4/15 (27%)
		TM helix 5	209..232	CDD:320259	8/27 (30%)
		TM helix 6	260..282	CDD:320259	11/21 (52%)
		TM helix 7	300..325	CDD:320259	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020