Protein Alignment PK1-R and ghsra

DIOPT Version :10

• Sequence 1: NP_001014620.1
• Gene: PK1-R / 41713
• FlyBaseID: FBgn0038201
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_001139744.1
• Gene: ghsra / 795753
• ZFINID: ZDB-GENE-070912-238
• Length: 360
• Species: Danio rerio
• Alignment Length: 384
• Identity: 116/384 - (30%)
• Similarity: 174/384 - (45%)
• Gaps: 98/384 - (25%)

  Fly    16 PLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSY 80
            |:.::..|||...|.|..||.||:.|.:|:.|.:.|.|.||.||.|:|.||.|:.|. :|.::..
Zfish    33 PIPVLTGVTVTCVLFFFVGVTGNLMTILVVTKYKDMRTTTNLYLSSMAFSDLLIFLC-MPLDLYR 96

  Fly    81 IWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVLV 145
            ||...|:.||..:|.....::|....:|:|.|||.:||||.|||.|...:.:....|...:|:::
Zfish    97 IWRYRPWNFGNILCKLFQFVSECCTYSTILNITALSVERYFAICFPLRAKVVVTKGRVRGVILVL 161

  Fly   146 WIMAIVTAIPQAAQFGIEHYSG-----VEQC---------GIVRVIVKHSFQLSTFIFFLAPMSI 196
            ||::..:|.|.....|:||.:|     ..:|         |::.::|..|     .|||..|:..
Zfish   162 WIVSFFSAGPVFVLVGVEHENGTNSWDTNECKATEYAIRSGLLTIMVWVS-----SIFFFLPVFC 221

  Fly   197 ILVLYLLIGVHLY---RSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAG 258
            :.|||.|||..|:   |.|:.|..:|
Zfish   222 LTVLYSLIGRKLWKRKRETIGENASS--------------------------------------- 247

  Fly   259 LMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIYAPARGAKLRDQHEF 323
                        |.:.|    |:.::||..||..|.|||.|||..|.:...:...|:.
Zfish   248 ------------RDKSN----RQTVKMLAVVVFAFVLCWLPFHVGRYLISKSTEMGSP------- 289

  Fly   324 VYTVMTY----VSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFGKK--------VSKG 370
            |.:::::    :|.||:|||..|||:||||||.|:|.| ...|||.:        |:||
Zfish   290 VMSIISHYCNLISFVLFYLSAAINPILYNIMSKKYRMA-ACKLFGLRNIPRRSTSVAKG 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	108/357 (30%)
		TM helix 1	21..48	CDD:320262	11/26 (42%)
		TM helix 2	55..81	CDD:320262	11/25 (44%)
		TM helix 3	94..124	CDD:320262	12/29 (41%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	12/28 (43%)
		TM helix 6	277..307	CDD:320262	13/29 (45%)
		TM helix 7	326..351	CDD:320262	13/28 (46%)
ghsra	NP_001139744.1	7tm_GPCRs	38..328	CDD:475119	109/358 (30%)
		TM helix 1	40..64	CDD:410628	11/23 (48%)
		TM helix 2	73..94	CDD:410628	10/21 (48%)
		TM helix 3	111..133	CDD:410628	6/21 (29%)
		TM helix 4	156..172	CDD:410628	4/15 (27%)
		TM helix 5	204..227	CDD:410628	8/27 (30%)
		TM helix 6	256..278	CDD:410628	11/21 (52%)
		TM helix 7	296..321	CDD:410628	13/24 (54%)