Protein Alignment PK1-R and NTSR1

DIOPT Version :10

• Sequence 1: NP_001014620.1
• Gene: PK1-R / 41713
• FlyBaseID: FBgn0038201
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_002522.2
• Gene: NTSR1 / 4923
• HGNCID: 8039
• Length: 418
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 124/425 - (29%)
• Similarity: 197/425 - (46%)
• Gaps: 84/425 - (19%)

  Fly     2 SAGNMSHD-LGPPRDPLAI------VIPVTVVYSLIFITGVVGNISTCIVI---KKNRSMHTATN 56
            ::||.|.. |..|...|.:      .:.||.||..:|:.|.|||..|...:   |..:|:.:..:
Human    38 ASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVH 102

  Fly    57 YYLFSLAISDFLLLLSGVPQEV-SYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERY 120
            |:|.|||:||.|.||..:|.|: ::||..:|:.||:..|.|...|.:....||.|.:.:.:||||
Human   103 YHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERY 167

  Fly   121 IAICHPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYS--GVEQCGIV------RVI 177
            :||||||..:.:...||..:.|..:|:.:.:.|:|.....|.::.|  |....|:|      ...
Human   168 LAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTAT 232

  Fly   178 VKHSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSG 242
            ||...|::||:.|:.||.:|.||          :|::....:|..||..:.....|:    ||..
Human   233 VKVVIQVNTFMSFIFPMVVISVL----------NTIIANKLTVMVRQAAEQGQVCTV----GGEH 283

  Fly   243 TAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIA 307
            :..|                    ::...||:.  ..|..:|:|.|||:.|.:||.|:|.:||:.
Human   284 STFS--------------------MAIEPGRVQ--ALRHGVRVLRAVVIAFVVCWLPYHVRRLMF 326

  Fly   308 IYAPARGAKLRDQH--EFVYTVMTY---VSGVLYYLSTCINPLLYNIMSHKFREAFKAVL----- 362
            .|       :.|:.  .|:|....|   |:..|:|:|:.|||:|||::|..||..|.|.|
Human   327 CY-------ISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCP 384

  Fly   363 ----------FGKKVSKGSLNSRNNIESRRLRRAL 387
                      |.:|..  |::|.:.:.|...|..|
Human   385 VWRRRRKRPAFSRKAD--SVSSNHTLSSNATRETL 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	108/353 (31%)
		TM helix 1	21..48	CDD:320262	11/29 (38%)
		TM helix 2	55..81	CDD:320262	12/26 (46%)
		TM helix 3	94..124	CDD:320262	11/29 (38%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	11/28 (39%)
		TM helix 6	277..307	CDD:320262	13/29 (45%)
		TM helix 7	326..351	CDD:320262	11/27 (41%)
NTSR1	NP_002522.2	7tmA_NTSR1	64..375	CDD:320477	108/353 (31%)
		TM helix 1	64..91	CDD:320477	10/26 (38%)
		TM helix 2	101..127	CDD:320477	12/25 (48%)
		TM helix 3	141..171	CDD:320477	11/29 (38%)
		TM helix 4	183..205	CDD:320477	6/21 (29%)
		TM helix 5	233..262	CDD:320477	12/38 (32%)
		TM helix 6	296..326	CDD:320477	13/31 (42%)
		Neurotensin binding. /evidence=ECO:0000250	321..344		6/29 (21%)
		TM helix 7	343..368	CDD:320477	11/24 (46%)