DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and NTSR1

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_002522.2	Gene:	NTSR1 / 4923	HGNCID:	8039	Length:	418	Species:	Homo sapiens

Alignment Length:	425	Identity:	124/425 - (29%)
Similarity:	197/425 - (46%)	Gaps:	84/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAGNMSHD-LGPPRDPLAI------VIPVTVVYSLIFITGVVGNISTCIVI---KKNRSMHTATN 56
            ::||.|.. |..|...|.:      .:.||.||..:|:.|.|||..|...:   |..:|:.:..:
Human    38 ASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVH 102

  Fly    57 YYLFSLAISDFLLLLSGVPQEV-SYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERY 120
            |:|.|||:||.|.||..:|.|: ::||..:|:.||:..|.|...|.:....||.|.:.:.:||||
Human   103 YHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERY 167

  Fly   121 IAICHPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYS--GVEQCGIV------RVI 177
            :||||||..:.:...||..:.|..:|:.:.:.|:|.....|.::.|  |....|:|      ...
Human   168 LAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTAT 232

  Fly   178 VKHSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSG 242
            ||...|::||:.|:.||.:|.||          :|::....:|..||..:.....|:    ||..
Human   233 VKVVIQVNTFMSFIFPMVVISVL----------NTIIANKLTVMVRQAAEQGQVCTV----GGEH 283

  Fly   243 TAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIA 307
            :..|                    ::...||:.  ..|..:|:|.|||:.|.:||.|:|.:||:.
Human   284 STFS--------------------MAIEPGRVQ--ALRHGVRVLRAVVIAFVVCWLPYHVRRLMF 326

  Fly   308 IYAPARGAKLRDQH--EFVYTVMTY---VSGVLYYLSTCINPLLYNIMSHKFREAFKAVL----- 362
            .|       :.|:.  .|:|....|   |:..|:|:|:.|||:|||::|..||..|.|.|
Human   327 CY-------ISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCP 384

  Fly   363 ----------FGKKVSKGSLNSRNNIESRRLRRAL 387
                      |.:|..  |::|.:.:.|...|..|
Human   385 VWRRRRKRPAFSRKAD--SVSSNHTLSSNATRETL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	108/353 (31%)
		TM helix 1	21..48	CDD:320262	11/29 (38%)
		TM helix 2	55..81	CDD:320262	12/26 (46%)
		TM helix 3	94..124	CDD:320262	11/29 (38%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	11/28 (39%)
		TM helix 6	277..307	CDD:320262	13/29 (45%)
		TM helix 7	326..351	CDD:320262	11/27 (41%)
NTSR1	NP_002522.2	7tm_1	80..364	CDD:278431	95/326 (29%)
		7tm_4	<159..381	CDD:304433	76/264 (29%)
		Neurotensin binding. /evidence=ECO:0000250	321..344		6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020