DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and GHSR

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_940799.1	Gene:	GHSR / 2693	HGNCID:	4267	Length:	366	Species:	Homo sapiens

Alignment Length:	415	Identity:	124/415 - (29%)
Similarity:	188/415 - (45%)	Gaps:	89/415 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAGNMSHDLGPPRD----------PLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTAT 55
            ::..::..|..|..|          |..::..||.....:|:.|:.||:.|.:|:.:.|.:.|.|
Human    14 LTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTT 78

  Fly    56 NYYLFSLAISDFLLLLSGVPQEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERY 120
            |.||.|:|.||.|:.|. :|.::..:|...|:.||:.:|.....::|:...||||||||.:||||
Human    79 NLYLSSMAFSDLLIFLC-MPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERY 142

  Fly   121 IAICHPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYSGVE-----QC--------- 171
            .|||.|...:.:....|...:|.::|.:|..:|.|.....|:||.:|.:     :|
Human   143 FAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRS 207

  Fly   172 GIVRVIVKHSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILY 236
            |::.|:|..|     .|||..|:..:.|||.|||..|:|           ||:      .|.::
Human   208 GLLTVMVWVS-----SIFFFLPVFCLTVLYSLIGRKLWR-----------RRR------GDAVV- 249

  Fly   237 RYGGSGTAMSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFH 301
                                       ||.|..    .||   ::.::||..||..|.|||.|||
Human   250 ---------------------------GASLRD----QNH---KQTVKMLAVVVFAFILCWLPFH 280

  Fly   302 AQRLIAIYAPARGAKLRDQHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFGKK 366
            ..|.:...:...|:....|   :......||.||:|||..|||:||||||.|:|.|...:|..:.
Human   281 VGRYLFSKSFEPGSLEIAQ---ISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEP 342

  Fly   367 VSKGSLNSRNNIESRRLRRALTNSS 391
            .|:..|::..:..|    ||.|.||
Human   343 FSQRKLSTLKDESS----RAWTESS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	110/350 (31%)
		TM helix 1	21..48	CDD:320262	8/26 (31%)
		TM helix 2	55..81	CDD:320262	11/25 (44%)
		TM helix 3	94..124	CDD:320262	15/29 (52%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	12/28 (43%)
		TM helix 6	277..307	CDD:320262	12/29 (41%)
		TM helix 7	326..351	CDD:320262	14/24 (58%)
GHSR	NP_940799.1	7tmA_GHSR	44..334	CDD:320259	110/350 (31%)
		TM helix 1	44..71	CDD:320259	8/26 (31%)
		TM helix 2	78..103	CDD:320259	11/25 (44%)
		TM helix 3	116..146	CDD:320259	15/29 (52%)
		TM helix 4	158..180	CDD:320259	6/21 (29%)
		TM helix 5	209..238	CDD:320259	13/33 (39%)
		TM helix 6	256..286	CDD:320259	14/32 (44%)
		TM helix 7	302..327	CDD:320259	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.050