DRSC/TRiP Functional Genomics Resources

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Protein Alignment PK1-R and NTSR2

DIOPT Version :9

Sequence 1:NP_001014620.1 Gene:PK1-R / 41713 FlyBaseID:FBgn0038201 Length:430 Species:Drosophila melanogaster
Sequence 2:NP_036476.2 Gene:NTSR2 / 23620 HGNCID:8040 Length:410 Species:Homo sapiens


Alignment Length:370 Identity:102/370 - (27%)
Similarity:171/370 - (46%) Gaps:71/370 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 TVVYSLIFITGVVGN-ISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEV-SYIWSKYP 86
            |.:|:||:..|..|| :|..:|:|..........:::.|||::..||||.|||.|: |::|..||
Human    36 TALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYP 100

  Fly    87 YVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVLVWIMAIV 151
            :|||:..|.|...:.|..|.||||::...:.||.:|:|.|...:::....|...::.|.|..::.
Human   101 WVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLG 165

  Fly   152 TAIPQAAQFGIEH-----------YSGVEQCGIVRVIVKHSFQLSTFIFFLAPMSI------ILV 199
            .|:|.|...|.:|           .|.|....:.|..::...|::..:.|:.|:::      :.|
Human   166 LALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTV 230

  Fly   200 LYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAGLMGG-- 262
            .:||.......||...|.::.:|.:.|..                            .||:..  
Human   231 SHLLALCSQVPSTSTPGSSTPSRLELLSE----------------------------EGLLSFIV 267

  Fly   263 ------SGAQLSSVRGRLNHYGTRRV------LRMLVAVVVCFFLCWAPFHAQRLIAIYAP--AR 313
                  .|.|:|.||    |...||:      :::|.|:||.:.:||.|:||:||:..|.|  |.
Human   268 WKKTFIQGGQVSLVR----HKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAW 328

  Fly   314 GAKLRDQHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAF 358
            ...|.:.:.:.|    .|:..|:|:|:.:.|||||.:|..||:.|
Human   329 TDPLYNFYHYFY----MVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PK1-RNP_001014620.1 7tmA_capaR 21..358 CDD:320262 101/368 (27%)
TM helix 1 21..48 CDD:320262 10/24 (42%)
TM helix 2 55..81 CDD:320262 12/26 (46%)
TM helix 3 94..124 CDD:320262 11/29 (38%)
TM helix 4 136..158 CDD:320262 5/21 (24%)
TM helix 5 178..207 CDD:320262 6/34 (18%)
TM helix 6 277..307 CDD:320262 13/35 (37%)
TM helix 7 326..351 CDD:320262 9/24 (38%)
NTSR2NP_036476.2 7tmA_NTSR2 33..369 CDD:320478 101/368 (27%)
TM helix 1 33..60 CDD:320478 9/23 (39%)
TM helix 2 68..94 CDD:320478 11/25 (44%)
TM helix 3 108..138 CDD:320478 11/29 (38%)
TM helix 4 152..170 CDD:320478 3/17 (18%)
TM helix 5 203..232 CDD:320478 4/28 (14%)
TM helix 6 290..320 CDD:320478 11/29 (38%)
TM helix 7 337..362 CDD:320478 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D380940at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24243
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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