DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and nmur-3

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001024524.1	Gene:	nmur-3 / 184090	WormBaseID:	WBGene00017176	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	114/396 - (28%)
Similarity:	188/396 - (47%)	Gaps:	60/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AIVIPV-TVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSYI 81
            |.:.|: |:::..:.:.|::||:.|.|||.|..|:|:.|||:|.:||.|||.|::.||..::..|
Worm    72 AFLNPILTLIFVFVGLVGLIGNLLTVIVIFKTNSLHSHTNYFLANLATSDFCLIVVGVSFDLVNI 136

  Fly    82 WS-KYPY-VFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVL 144
            |: :.|. :||  .|............|::|||...|.||:.|||:||..:.:....|..|.|:|
Worm   137 WNDEEPLDIFG--YCSLTSTFISLFTFASILTIVLLTAERFTAICYPFSHRTIFDEKRVKRFILL 199

  Fly   145 VWIMAIVTAIPQAAQFGIEHYSGVEQ--CGIVRVIV---------------KHSFQLSTFIFFLA 192
            :|.:|::.:|...:.|     ..|.|  ||..|.:.               ::.|:.:..|.|:.
Worm   200 IWFVALLPSIFIGSMF-----KRVSQDFCGFNRQMTYIGRCDLVTSPDSFFRYPFESAITITFVL 259

  Fly   193 PMSIILVLY---------LLIGVHL-YRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSF 247
            |:..|:..|         |.|.|:| |.|.:.  |.::........|.:..        |||.|.
Worm   260 PLFFIIYCYFRILGTRHFLCITVNLSYTSNIF--PVTLNEMSNSTHVHTPV--------GTARSD 314

  Fly   248 NGGGSGAGTAGLMGGSGAQLS----SVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAI 308
            :|......|:.........|:    :|:...:....:.|::|||.|...||:|:.|:||||||..
Worm   315 SGAFPFPHTSNNSNTQSFPLTVHTKNVQPPRSQQAQKMVIKMLVTVTAVFFVCYLPYHAQRLIVK 379

  Fly   309 YAPARGAKLRDQHEFVYTVMTY-VSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFGKKVSKGSL 372
            |      ..:|.....:..:.| ::|:|.|:|..:||:.||:||.:||..||.::  |.|.....
Worm   380 Y------NSKDCSNSDFCKLLYPIAGILQYISASLNPIFYNLMSVRFRNGFKKLI--KDVWAHRA 436

  Fly   373 NSRNNI 378
            .|.:|:
Worm   437 RSYSNL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	107/371 (29%)
		TM helix 1	21..48	CDD:320262	9/27 (33%)
		TM helix 2	55..81	CDD:320262	12/25 (48%)
		TM helix 3	94..124	CDD:320262	9/29 (31%)
		TM helix 4	136..158	CDD:320262	7/21 (33%)
		TM helix 5	178..207	CDD:320262	8/52 (15%)
		TM helix 6	277..307	CDD:320262	14/29 (48%)
		TM helix 7	326..351	CDD:320262	9/25 (36%)
nmur-3	NP_001024524.1	7tmA_NTSR-like	76..424	CDD:320110	107/370 (29%)
		TM helix 1	78..102	CDD:320110	8/23 (35%)
		TM helix 2	111..133	CDD:320110	11/21 (52%)
		TM helix 3	150..172	CDD:320110	4/21 (19%)
		TM helix 4	195..211	CDD:320110	6/15 (40%)
		TM helix 5	246..269	CDD:320110	5/22 (23%)
		TM helix 6	351..376	CDD:320110	12/24 (50%)
		TM helix 7	392..417	CDD:320110	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950