DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and Ntsr1

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_061236.1	Gene:	Ntsr1 / 18216	MGIID:	97386	Length:	424	Species:	Mus musculus

Alignment Length:	424	Identity:	121/424 - (28%)
Similarity:	195/424 - (45%)	Gaps:	79/424 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AGNMSHDLGPPRDPLAI------VIPVTVVYSLIFITGVVGNISTCIVI---KKNRSMHTATNYY 58
            :||.|..:..|...|.:      .:.||.||..:|:.|.|||..|...:   |..:|:.:..:|:
Mouse    40 SGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYH 104

  Fly    59 LFSLAISDFLLLLSGVPQEV-SYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIA 122
            |.|||:||.|:||..:|.|: ::||..:|:.||:..|.|...|.:....||.|.:.:.:||||:|
Mouse   105 LGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLA 169

  Fly   123 ICHPFLGQAMSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYS--GVEQCGIV------RVIVK 179
            |||||..:.:...||..:.|..:|:.:.:.|:|.....|:::.|  |....|:|      ...||
Mouse   170 ICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVK 234

  Fly   180 HSFQLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTA 244
            ...|::||:.||.||.||.:|..:|...|  :.:|...|...|
Mouse   235 VVIQVNTFMSFLFPMLIISILNTVIANKL--TVMVHQAAEQGR---------------------- 275

  Fly   245 MSFNGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIY 309
                 |....||...:..|...:|...||:.  ..|..:.:|.|||:.|.:||.|:|.:||:..|
Mouse   276 -----GVCTVGTHNSLEHSTFNMSIEPGRVQ--ALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCY 333

  Fly   310 APARGAKLRDQH--EFVYTVMTY---VSGVLYYLSTCINPLLYNIMSHKFREAFKAVL------- 362
                   :.|:.  .|::....|   ::..|:|:|:.|||:|||::|..||:.|.:.|
Mouse   334 -------ISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGW 391

  Fly   363 ---------FGKKVSKGSLNSRNNIESRRLRRAL 387
                     |.:|  ..|::|.:...:...|..|
Mouse   392 RRRRKKRPTFSRK--PNSMSSNHAFSTSATRETL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	108/353 (31%)
		TM helix 1	21..48	CDD:320262	11/29 (38%)
		TM helix 2	55..81	CDD:320262	12/26 (46%)
		TM helix 3	94..124	CDD:320262	11/29 (38%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	13/28 (46%)
		TM helix 6	277..307	CDD:320262	12/29 (41%)
		TM helix 7	326..351	CDD:320262	10/27 (37%)
Ntsr1	NP_061236.1	7tm_1	80..369	CDD:278431	95/326 (29%)
		Neurotensin binding. /evidence=ECO:0000250	326..349		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..424		6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020