DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and nmur2

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_002940961.1	Gene:	nmur2 / 100498226	XenbaseID:	XB-GENE-6046084	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	136/414 - (32%)
Similarity:	213/414 - (51%)	Gaps:	86/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GPPRDPLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVP 75
            ||.|..|:  :|:|:||:.||:.||:||...|:||.|:.:|.|.|||||||||:||.|:||.|:|
Frog    37 GPKRSRLS--LPMTLVYATIFLIGVIGNTLVCLVILKHHNMRTPTNYYLFSLAVSDLLVLLLGMP 99

  Fly    76 QEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIR 140
            .||..:||.||::||.:.|..:.:|.||...|::|::|..:||||:||.|||..:..|..|||::
Frog   100 LEVYEMWSNYPFLFGAWGCYFKTVLFETVCFASILSVTTVSVERYVAIIHPFQAKLKSTRSRALK 164

  Fly   141 IIVLVWIMAIVTAIPQAAQFGI--EHYSG------VEQCGIVRVIVKHS--FQLSTFIFFLAPMS 195
            |:|.:||.:|:.:||..:..||  :::..      ...|.:|:.:..::  .|:::.:|::.||.
Frog   165 ILVTLWIFSILFSIPNTSTHGILLQYFPNGSLIPDSATCTVVQPLWIYNCIIQVTSLLFYILPMG 229

  Fly   196 IILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAGLM 260
            :|.|||.|:|:.|      .|..|:                    ....||.|
Frog   230 VISVLYCLMGIKL------RGDHSL--------------------EADKMSVN------------ 256

  Fly   261 GGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIYA-----PARGAKLRDQ 320
                         :.....:.:.:||..:|:.|.:||||||..||...:.     |...|
Frog   257 -------------VQRPSRKSITKMLFVLVMVFGICWAPFHVDRLFFSFVLDWTEPLANA----- 303

  Fly   321 HEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVL--FGKKVSKGSLNSRNNIESRRL 383
                :.:...||||.:|||:.:|||:||::|.:||.||:.||  |.|     ||..:..::|  |
Frog   304 ----FNLTHVVSGVFFYLSSAVNPLIYNLLSRRFRSAFQNVLPPFFK-----SLKPKIPVQS--L 357

  Fly   384 RRALTNSSQTQRFSIESAEQPKPS 407
            ....:....|.|..::|.|:..||
Frog   358 APPKSTLILTVRNRMDSGEEGSPS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	116/351 (33%)
		TM helix 1	21..48	CDD:320262	13/26 (50%)
		TM helix 2	55..81	CDD:320262	18/25 (72%)
		TM helix 3	94..124	CDD:320262	12/29 (41%)
		TM helix 4	136..158	CDD:320262	10/21 (48%)
		TM helix 5	178..207	CDD:320262	10/30 (33%)
		TM helix 6	277..307	CDD:320262	12/29 (41%)
		TM helix 7	326..351	CDD:320262	12/24 (50%)
nmur2	XP_002940961.1	7tmA_NMU-R2	45..337	CDD:320479	116/351 (33%)
		TM helix 1	45..72	CDD:320479	13/26 (50%)
		TM helix 2	79..105	CDD:320479	18/25 (72%)
		TM helix 3	118..148	CDD:320479	12/29 (41%)
		TM helix 4	160..182	CDD:320479	10/21 (48%)
		TM helix 5	212..241	CDD:320479	10/28 (36%)
		TM helix 6	260..290	CDD:320479	12/29 (41%)
		TM helix 7	305..330	CDD:320479	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0001494
OrthoInspector	1	1.000	-	-		mtm9540
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.050