DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK1-R and ghsr

DIOPT Version :9

Sequence 1:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_002931618.1	Gene:	ghsr / 100497774	XenbaseID:	XB-GENE-484475	Length:	359	Species:	Xenopus tropicalis

Alignment Length:	396	Identity:	121/396 - (30%)
Similarity:	187/396 - (47%)	Gaps:	86/396 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SHDLGPPRDPLAIV-IPV----TVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISD 66
            |::...|.||:.:. :||    ||...|:||.|:.||:.|.:|:.|.:.|.|.||.||.|:|.||
Frog    18 SNNYSWPEDPVFLFPVPVLTGITVTCILLFIIGISGNVMTMLVVSKYKDMRTTTNLYLSSMAFSD 82

  Fly    67 FLLLLSGVPQEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQA 131
            .|:.|. :|.::..:|...|:.||..:|.....::|....:|:|.|||.:||||.|||.|...:.
Frog    83 LLIFLC-MPLDLYRLWQYRPWNFGSSLCKLFQFVSECCTYSTILNITALSVERYFAICFPLKAKV 146

  Fly   132 MSKLSRAIRIIVLVWIMAIVTAIPQAAQFGIEHYSG-----VEQC---------GIVRVIVKHSF 182
            :....|...:|.::|.::.|:|.|.....|:||.:|     ..:|         |::.::|
Frog   147 VITKGRVKLVISVLWAVSFVSAGPIFVLVGVEHENGTNPLDTNECKATEYAIKSGLLTIMV---- 207

  Fly   183 QLSTFIFFLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSF 247
             .::.|||..|:..:.|||.|||..|:|           |::       :||
Frog   208 -WTSSIFFFLPVFCLTVLYTLIGRKLWR-----------RKR-------ETI------------- 240

  Fly   248 NGGGSGAGTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLI---AIY 309
                 |..|            |:|.:.|    ::.::||..||..|.|||.|||..|.:   :..
Frog   241 -----GPHT------------SIRDKHN----KQTVKMLAVVVFAFILCWLPFHVARYLFSKSFE 284

  Fly   310 APARGAKLRDQHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVLFGKKVSKGSLNS 374
            |.:....|..|:      ...||.||:|||..|||:||||||.|:|.|...:...|:||:.:..:
Frog   285 AGSLEIALISQY------CNLVSFVLFYLSAAINPILYNIMSKKYRVAACRLFRLKQVSRKATYT 343

  Fly   375 RNNIES 380
            .|:..|
Frog   344 TNDESS 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	111/357 (31%)
		TM helix 1	21..48	CDD:320262	12/30 (40%)
		TM helix 2	55..81	CDD:320262	11/25 (44%)
		TM helix 3	94..124	CDD:320262	12/29 (41%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	11/28 (39%)
		TM helix 6	277..307	CDD:320262	12/32 (38%)
		TM helix 7	326..351	CDD:320262	14/24 (58%)
ghsr	XP_002931618.1	7tm_4	48..334	CDD:304433	106/349 (30%)
ghsr	XP_002931618.1	7tm_1	53..316	CDD:278431	95/326 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050