Protein Alignment foxo and FOXQ1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_150285.3
• Gene: FOXQ1 / 94234
• HGNCID: 20951
• Length: 403
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 108/437 - (24%)
• Similarity: 149/437 - (34%)
• Gaps: 162/437 - (37%)

  Fly    10 PRLTHTD-NGLAMDQLGG-DLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDS---------- 62
            ||..|.| .|..::..|| |.|     .|.:.|..               |.|.|
Human     8 PRAAHGDKQGSDLEGAGGSDAP-----SPLSAAGD---------------DSLGSDGDCAANSPA 52

  Fly    63 -------TKASNQQLAPG--DSQQAIQNANA-------------------------AKKNSSRRN 93
                   |:...:|.|.|  .:::||..|.|                         |:.....|.
Human    53 AGGGARDTQGDGEQSAGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGGAGSGEGARSKPYTRR 117

  Fly    94 AWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRF 158
            .....||..||..||..:...||||::|.|:::...|:|:     .|..||:||:||||||::.|
Human   118 PKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFR-----GSYTGWRNSVRHNLSLNDCF 177

  Fly   159 MRVQNEGT---GKSSWWMLNPEAK----PGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVV 216
            ::|..:.:   ||.::|||||.::    .|...|||         ::...||......||.....
Human   178 VKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRR---------KRLSHRAPVPAPGLRPEEAP 233

  Fly   217 GLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQ--RASSNASSCGRLS----------- 268
            || .|.|.|:          |.:|        .||..|.  |....||..|:.|
Human   234 GL-PAAPPPA----------PAAP--------ASPRMRSPARQEERASPAGKFSSSFAIDSILRK 279

  Fly   269 PIRA---QDLEP----DWG---------FPVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQ 317
            |.|:   :|..|    .||         ||     ..:..|..:||..|....|.|     ..:.
Human   280 PFRSRRLRDTAPGTTLQWGAAPCPPLPAFP-----ALLPAAPCRALLPLCAYGAGE-----PARL 334

  Fly   318 GFSAASGLPSQPP----PPPYQPPQHQQAQQQQQQQSPYALNGPASG 360
            |...|...|:.||    |.|...|..             .|.|||:|
Human   335 GAREAEVPPTAPPLLLAPLPAAAPAK-------------PLRGPAAG 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	31/81 (38%)
FOXQ1	NP_150285.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		18/86 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..116		1/21 (5%)
		FH_FOXQ1-like	119..197	CDD:410808	31/82 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..266		17/68 (25%)