DRSC/TRiP Functional Genomics Resources

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Protein Alignment foxo and FOXH1

DIOPT Version :10

Sequence 1:NP_650330.3 Gene:foxo / 41709 FlyBaseID:FBgn0038197 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_003914.1 Gene:FOXH1 / 8928 HGNCID:3814 Length:365 Species:Homo sapiens


Alignment Length:385 Identity:78/385 - (20%)
Similarity:127/385 - (32%) Gaps:123/385 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 SNQQLAPGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVP 130
            |..:|.|.:::...|.....||...|.:. ...:|..:|...|.:|..:||.|:||...:....|
Human     5 SGSRLGPPEAESPSQPPKRRKKRYLRHDK-PPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFP 68

  Fly   131 YFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGT---GKSSWWMLNPEAKPGKSVRRRAASME 192
            :|::..:     |||:|||||||.:..|.:|..:..   .|.::|.::....|.:::|     ::
Human    69 FFREDYE-----GWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALR-----LQ 123

  Fly   193 TSRYEKRRGRAKKRVEALRQAGVVGLND---ATPSPSSSVSEGLDHFPESPLHSGGGF-----QL 249
            .:...:|......|....:..|...|:.   ..|||....|||   |....|..|.|.     .|
Human   124 NTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEG---FSIKSLLGGSGEGAPWPGL 185

  Fly   250 SPDFRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADELTLCNQ 314
            :|              :.||:.|                              ||          
Human   186 AP--------------QSSPVPA------------------------------GT---------- 196

  Fly   315 QQQGFSAASGLPSQPPPPPYQP---------PQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQC 370
               |.|....:|:.|.|...:|         |...:.:..|         |.|.|.:||.|:.:.
Human   197 ---GNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQ---------GGAIGPSTLSPEPRA 249

  Fly   371 LLHRSLNCSCMHNARDG------------------LSPNSV-----TTTMSPAYPNSEPS 407
            .....|..:.:...|..                  .:||.|     ..|..|..|::.|:
Human   250 WPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPA 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
foxoNP_650330.3 FH_FOXO 96..175 CDD:410806 25/81 (31%)
FOXH1NP_003914.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 6/23 (26%)
FH_FOXH 33..111 CDD:410796 25/83 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..215 22/123 (18%)
SMAD-interaction domain (SID) 273..354 7/37 (19%)
Fast/FoxH1 motif 1 (FM1) 277..281 0/3 (0%)
Fast/FoxH1 motif 2 (FM2) 287..293 3/5 (60%)
SMAD interaction motif (SIM) 327..348
Blue background indicates that the domain is not in the aligned region.

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