| Sequence 1: | NP_001262557.1 | Gene: | foxo / 41709 | FlyBaseID: | FBgn0038197 | Length: | 622 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001178775.1 | Gene: | Foxo1 / 84482 | RGDID: | 620283 | Length: | 649 | Species: | Rattus norvegicus |
| Alignment Length: | 680 | Identity: | 215/680 - (31%) |
|---|---|---|---|
| Similarity: | 280/680 - (41%) | Gaps: | 227/680 - (33%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 31 DVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAA---------- 85
Fly 86 ----------------------------------------------------------------- 85
Fly 86 -----KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWK 145
Fly 146 NSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGRAKKRVE 208
Fly 209 ALRQAGVVGLNDATPSPSSSVSEGLDHFPESP-LHSGGGFQLSPDFRQRASSNASS-CGRLSPIR 271
Fly 272 AQDLEPDWG--------FPVDYQNTTMTQAHAQALEELTG-----TMADELTLCN---------- 313
Fly 314 -------QQQQGFSAASGLPS-QPPPPPY----------QPPQHQQAQQQQQQQSPYALNGPASG 360
Fly 361 YN---------------------------TLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMS 398
Fly 399 PAYPNSEPSSDSLNTYSNV------------------VLDGPADTAAL------MVQQQQQQQQQ 439
Fly 440 QQLSASLEDNNCASTLIGQC-----LEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGG 499
Fly 500 LLDINIPLATVNTNLVNSSSGPLSISNISN 529 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| foxo | NP_001262557.1 | FH | 95..175 | CDD:238016 | 69/79 (87%) |
| Foxo1 | NP_001178775.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..62 | 19/51 (37%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 112..151 | 3/38 (8%) | |||
| FH | 154..234 | CDD:238016 | 69/79 (87%) | ||
| DNA binding. /evidence=ECO:0000250 | 205..212 | 6/6 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 228..339 | 58/120 (48%) | |||
| DNA binding. /evidence=ECO:0000250 | 228..231 | 2/2 (100%) | |||
| Nuclear localization signal. /evidence=ECO:0000250 | 245..247 | 1/1 (100%) | |||
| Sufficient for interaction with NLK. /evidence=ECO:0000250 | 277..557 | 69/309 (22%) | |||
| Required for interaction with RUNX2. /evidence=ECO:0000250 | 357..453 | 20/98 (20%) | |||
| FOXO_KIX_bdg | 417..494 | CDD:293280 | 13/90 (14%) | ||
| Required for interaction with SIRT1. /evidence=ECO:0000250 | 456..460 | 0/3 (0%) | |||
| FOXO-TAD | 591..627 | CDD:293281 | 10/44 (23%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 155 | 1.000 | Domainoid score | I4131 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG2294 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 292 | 1.000 | Inparanoid score | I2689 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1160384at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000837 | |
| OrthoInspector | 1 | 1.000 | - | - | otm45200 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR45767 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X489 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 12 | 11.930 | |||||