Protein Alignment foxo and foxo1a

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001070725.2
• Gene: foxo1a / 768121
• ZFINID: ZDB-GENE-061013-59
• Length: 652
• Species: Danio rerio
• Alignment Length: 670
• Identity: 225/670 - (33%)
• Similarity: 290/670 - (43%)
• Gaps: 187/670 - (27%)

  Fly    20 AMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKAS------------------ 66
            |.:|:   :.:|..|||.:|.||.|||.|||| |..|. ..||..:|
Zfish     5 AQNQM---VEIDPDFEPLSRPRSCTWPLPRPE-FPNPA-AADSNTSSPAPSVKQEPSSTADFINN 64

  Fly    67 -----------------------------NQQLAPGDSQQ----------AIQNANAA--KKNSS 90
                                         :||..|...||          |...|.||  |.:||
Zfish    65 LSLLEENEDYPDQKPLMLCSEFQCQENCIHQQQIPSQQQQVPVLSSPVAAAAAAAAAAQRKSSSS 129

  Fly    91 RRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLH 155
            |||||||:|||||||.||.|:.:|||||||||:|||::|||||||||||||||||||||||||||
Zfish   130 RRNAWGNMSYADLITKAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLH 194

  Fly   156 NRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGRAKKRVEALRQAGVVGL 218
            :||:|||||||||||||||||| .|.|||.|||||||: .|::.|.||||.|:..|| |.|..|.
Zfish   195 SRFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKLAL-QGGPEGG 258

  Fly   219 NDATPSPSSSVSEGLDHFPESP-LHSGGGFQLSPDFRQRASSNASS-CGRLSPI---RAQDLEPD 278
            .|   ||.|...:    :|.|| .||...|:....||.|.|||||: .|||||.   ...|.:..
Zfish   259 AD---SPGSQYGK----WPGSPNSHSNDDFEAWTAFRPRTSSNASTLSGRLSPFIDDELGDSDVH 316

  Fly   279 WGFPVDYQNTTMTQAHAQALEELTGTMA------------DELTLCNQQQQG----------FSA 321
            ..:|.....|.||.. ..:|.|:.|::.            |.|.|.:.:...          .|.
Zfish   317 MVYPGPGSGTKMTST-LPSLSEMAGSLGHSGSENVMENLLDNLNLLSPKNPSTGGPGSGSNQSSP 380

  Fly   322 ASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRS----------- 375
            :|.:.:.|...||..|......||.||.....|.|.| |..::.|.....|..|
Zfish   381 SSLMQASPGYSPYSSPGLSAVSQQTQQDFRKCLYGQA-GMGSMSPMPMQPLPESKPSFGPGGGTM 444

  Fly   376 --LNCS---------------------------------CM----HNARDGLSPNSVTTTMSPAY 401
              .||:                                 ||    .:.|:.|.....|.:.:.::
Zfish   445 GQFNCTAGLLKELLTSDGEPGDLMPSVDTVVSQSAGGSGCMLPPYSSGRNELMGGGPTHSHTLSH 509

  Fly   402 PN-----SEPSSDSLNTYS--NVVLDGPADTAALMVQQQQQQQQQQQLSASLEDN---NCASTLI 456
            |:     :.|:|.:||..|  .:...|.:.....:...:...|.|...|..|...   .|:.:..
Zfish   510 PHNMHGQAPPTSVALNGRSLHPLTAIGHSSVGGRLGSGKSPMQMQYGGSGHLGGGLPPYCSMSSN 574

  Fly   457 G----------QCLEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVN 511
            |          |.|:.|  |..|.|   |:..|:...||:||.:|...:..|..||.|.
Zfish   575 GYGRGPGMMAHQQLQHL--EKLPSD---LDGMPIERFECDVESILHDTLMDGESLDFNF------ 628

  Fly   512 TNLVNSSSG--PLSISNISN 529
             :.:||..|  |.|:...::
Zfish   629 -DPMNSQQGFVPHSVKTTTH 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	67/78 (86%)
foxo1a	NP_001070725.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		21/56 (38%)
		FH_FOXO1	125..223	CDD:410834	81/97 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..277		39/76 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	359..406		9/46 (20%)
		FOXO_KIX_bdg	411..497	CDD:465228	12/86 (14%)
		FOXO-TAD	593..631	CDD:435506	13/47 (28%)