DRSC/TRiP Functional Genomics Resources

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Protein Alignment foxo and foxo1b

DIOPT Version :9

Sequence 1:NP_001262557.1 Gene:foxo / 41709 FlyBaseID:FBgn0038197 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001076326.1 Gene:foxo1b / 567969 ZFINID:ZDB-GENE-080425-3 Length:629 Species:Danio rerio


Alignment Length:646 Identity:211/646 - (32%)
Similarity:273/646 - (42%) Gaps:182/646 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LDVGFEPQTRARSNTWPCPRPE------------------------NFVEPTDELDST------- 63
            :|..|||.:|.||.|||..|||                        :|:.....|:.|       
Zfish    11 IDPDFEPLSRPRSCTWPLHRPEFSEQPGNSNTSSPAPSVKPEQGIVDFINSLSLLEETEDYPDEK 75

  Fly    64 ---------------------KASNQQL------------APGDSQQAIQNANAAKKNSSRRNAW 95
                                 :..|.||            |.|.|..|.|.    |.:|||||||
Zfish    76 PVLLNDFHCQDNCAHPQQQHPQQPNPQLTHPQQVPPLPAPASGSSPAAAQR----KSSSSRRNAW 136

  Fly    96 GNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMR 160
            ||:|||||||.||.|:.:|||||||||||||::|||||||||||||||||||||||||||:||:|
Zfish   137 GNMSYADLITKAIESSPEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVR 201

  Fly   161 VQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGRAKKRVEALRQAGVVGLNDATP 223
            ||||||||||||||||| .|.|||.||||.||: .|::.|.||||.|:..:|:.    ||:..:.
Zfish   202 VQNEGTGKSSWWMLNPEGGKSGKSPRRRATSMDNNSKFTKSRGRAAKKKMSLQG----GLDGGSN 262

  Fly   224 SPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASS-CGRLSPIRAQD---LEPDWGFPVD 284
            ||.|...:.|.. |.|  ||...|:...:||.||||:||: .||.||...::   .|...|:|  
Zfish   263 SPGSQYPKWLGS-PNS--HSNDDFEPWGNFRTRASSDASTLSGRRSPFLPEEDEAAEVHIGYP-- 322

  Fly   285 YQNTTMTQAHAQALEELTG-----TMADEL------------TLCNQQQQGFSAASGLPSQPPPP 332
               .|.......:|.|:.|     .|.|.|            |..:|:.|...::..:...|..|
Zfish   323 ---GTKLGGPLPSLSEVAGHHGSENMMDNLLENLNLISPKNNTQGSQEAQTALSSPLMQGSPGYP 384

  Fly   333 PYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRS-----------LNCSCMHNARD 386
            .|..| :...|.|.||.....|.| ..|...|.|.|...|..|           .||:      .
Zfish   385 SYTSP-NMGPQPQVQQDYRKCLYG-QGGVGGLNPISIPTLSDSKPGGYGPFVGQYNCA------P 441

  Fly   387 GLSPNSVTTTMSP--AYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQL----SAS 445
            ||....:|....|  ....|......|.:|::   .|.......|:.........:.|    |.:
Zfish   442 GLLKELLTADADPRGELMQSGEGQPVLPSYAS---QGQMAQGGKMITHPHLHAHPRSLHQLPSPA 503

  Fly   446 LEDNNCASTLIGQCLEVLNNEAQPI-----------DEFNLENFPVGN----------------- 482
            :..|.||....|..:.:.:.:.||.           .|..:.::..||                 
Zfish   504 MGLNGCAMLPHGHPVRLSSMKPQPHLPHHTHLGRGGGEAGMPSYTNGNGFHRHGAIAHHHHSHPE 568

  Fly   483 ---------------LECNVEELLQQEMSYGGLLDINI-PLA-------TVNTNLVNSSSG 520
                           :||:||.:|...:..|..||.|. |::       :|.|:..|..||
Zfish   569 RLPSDLDDMLIDQLDVECDVERVLHDTLMDGDALDFNFDPMSSQQSFTHSVKTSTHNWVSG 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
foxoNP_001262557.1 FH 95..175 CDD:238016 69/79 (87%)
foxo1bNP_001076326.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 13/42 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..134 12/49 (24%)
FH 136..216 CDD:238016 69/79 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..308 49/103 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..397 8/38 (21%)
FOXO_KIX_bdg 403..483 CDD:293280 18/89 (20%)
FOXO-TAD 569..609 CDD:293281 9/39 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 155 1.000 Domainoid score I4171
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 253 1.000 Inparanoid score I3174
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1160384at2759
OrthoFinder 1 1.000 - - FOG0000837
OrthoInspector 1 1.000 - - otm24727
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45767
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4575
SonicParanoid 1 1.000 - - X489
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1111.050

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