Protein Alignment foxo and Foxo3

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_062714.1
• Gene: Foxo3 / 56484
• MGIID: 1890081
• Length: 672
• Species: Mus musculus
• Alignment Length: 698
• Identity: 225/698 - (32%)
• Similarity: 289/698 - (41%)
• Gaps: 231/698 - (33%)

  Fly    27 DLPLDVGFEPQTRARSNTWPCPRPENFVEPT--------------------DELDSTKASNQQ-- 69
            ::.||..||||:|.||.|||..|||....|.                    ||....:||:..
Mouse    15 EVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDGGGRASSAMVI 79

  Fly    70 --------------------LAPGDSQQAIQNANAA----------------------------- 85
                                ||||........|:||
Mouse    80 GGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSGGTPTQLQPQQPLPQPQPGAAGGSG 144

  Fly    86 --KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSI 148
              :|.|||||||||||||||||.||.|:.||||||||||||||:.||||||||||||||||||||
Mouse   145 QPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSI 209

  Fly   149 RHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEALR 211
            |||||||:||||||||||||||||::||: .|.||:.||||.||:.| :|.|.||||.|:..||:
Mouse   210 RHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQ 274

  Fly   212 QAGVVGLNDATPSPSSSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA-- 272
            .|.    ..|..|||.     |..:|.||. .|........|||.|.:||||: .||||||.|
Mouse   275 AAP----ESADDSPSQ-----LSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILAST 330

  Fly   273 --QDLEPDWG--FPVDYQNTTMTQ--------AHAQALEELTGTM--------------ADELTL 311
              .|::.|.|  .|:.|.::....        .....|.::.|||              .|.:.|
Mouse   331 ELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIAL 395

  Fly   312 CNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPY-----ALNGPASGYNT--LQPQSQ 369
                         .||||.||        ....|:....||     .|..|...:|:  ..|.|.
Mouse   396 -------------PPSQPSPP--------GGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSL 439

  Fly   370 CLLHRSLNCSCMHN--------------------ARDGLSPNSVTTTMSPAYPN----------- 403
            ..|.:|...:...|                    |.|.||.:.|..|.|....:
Mouse   440 NSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNA 504

  Fly   404 ---------------SEPSSDSL-----------------------NTYSNVVLDGPADTAALMV 430
                           ::|:..||                       |:.||:   |.:|:::|..
Mouse   505 RRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNM---GLSDSSSLGS 566

  Fly   431 QQQQQQQQQQQLSASLEDNNCASTLIGQC--LEVLNNEAQP----IDEFNLENFPVGNLECNVEE 489
            .:.|||....|...:|.|:...|:|....  |.|:.::..|    :|.||      |:|||::|.
Mouse   567 AKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFN------GSLECDMES 625

  Fly   490 LLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSISNISNLSNISSNS 537
            :::.|:.....||.|........|:|.     |::.|.:.....||.|
Mouse   626 IIRSELMDADGLDFNFDSLISTQNVVG-----LNVGNFTGAKQASSQS 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	70/78 (90%)
Foxo3	NP_062714.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..85		20/69 (29%)
		Required for mitochondrial import. /evidence=ECO:0000250|UniProtKB:O43524	80..108		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..152		5/41 (12%)
		FH_FOXO3	156..238	CDD:410835	72/81 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..301		35/79 (44%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43524	241..258		10/16 (63%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000250|UniProtKB:O43524	299..672		89/405 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..441		12/49 (24%)
		FOXO_KIX_bdg	431..510	CDD:465228	12/78 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..583		10/50 (20%)
		FOXO-TAD	605..643	CDD:435506	13/43 (30%)