Protein Alignment foxo and Foxo1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Alignment Length: 662
• Identity: 218/662 - (32%)
• Similarity: 286/662 - (43%)
• Gaps: 188/662 - (28%)

  Fly    31 DVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAA---------- 85
            |..|||..|.||.|||.|||| |.:......|...|....|..|:..::.:|:|.
Mouse    11 DPDFEPLPRQRSCTWPLPRPE-FNQSNSTTSSPAPSGGAAANPDAAASLASASAVSTDFMSNLSL 74

  Fly    86 ----------------------------------------------------------------- 85
                                                                             
Mouse    75 LEESEDFARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAA 139

  Fly    86 --------KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSA 142
                    |.:|||||||||||||||||.||.|:.:|||||||||||||::||||||||||||||
Mouse   140 GPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSA 204

  Fly   143 GWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGRAKK 205
            |||||||||||||::|:|||||||||||||||||| .|.|||.|||||||: .|::.|.||||.|
Mouse   205 GWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAK 269

  Fly   206 RVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESP-LHSGGGFQLSPDFRQRASSNASS-CGRLS 268
            :..:| |:|..|..|   ||.|..|:    :|.|| .||...|.....||.|.|||||: .||||
Mouse   270 KKASL-QSGQEGPGD---SPGSQFSK----WPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLS 326

  Fly   269 PIRAQDLEPDWG--------FPVDYQNTTMTQAHAQALEELTG-----TMADELTLCN------- 313
            ||..:  :.|.|        :|........|   ..:|.|::.     .:.|.|.|.:
Mouse   327 PIMTE--QDDLGDGDVHSLVYPPSAAKMAST---LPSLSEISNPENMENLLDNLNLLSSPTSLTV 386

  Fly   314 ----------QQQQGFSAASGLPS-QPPPPPYQPPQHQQAQQQQQQQSP-YALNGPASGYNTLQP 366
                      ||...:|.|....| ..|.|.|....:.|:......|.| ..|....|.|..|.
Mouse   387 STQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGLN- 450

  Fly   367 QSQC---LLHRSLNC-SCMHN----------ARDG---------LSPNSV----------TTTMS 398
            |..|   ||...|.. |..||          |:..         :.||||          ...|:
Mouse   451 QYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMMN 515

  Fly   399 PA---YPNSEPSSDSLN--TYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCAS-TLIG 457
            |:   :|.....:.|:|  |..:||...| .|:|:......:...|..||..::.:...| :.:.
Mouse   516 PSSHTHPGHAQQTASVNGRTLPHVVNTMP-HTSAMNRLTPVKTPLQVPLSHPMQMSALGSYSSVS 579

  Fly   458 QC-----LEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVNTNLVNS 517
            .|     :.||:.|..|.|   |:...:..|:|::|.:::.::..|..||.|.      .|::.:
Mouse   580 SCNGYGRMGVLHQEKLPSD---LDGMFIERLDCDMESIIRNDLMDGDTLDFNF------DNVLPN 635

  Fly   518 SSGPLSISNISN 529
            .|.|.|:...::
Mouse   636 QSFPHSVKTTTH 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	68/78 (87%)
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		19/51 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		3/41 (7%)
		FH_FOXO1	148..246	CDD:410834	82/97 (85%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		58/120 (48%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		75/295 (25%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		21/96 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		4/26 (15%)
		FOXO_KIX_bdg	420..501	CDD:465228	19/81 (23%)
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463		1/3 (33%)
		FOXO-TAD	594..630	CDD:435506	10/44 (23%)