DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment foxo and foxo6a

DIOPT Version :9

Sequence 1:	NP_001262557.1	Gene:	foxo / 41709	FlyBaseID:	FBgn0038197	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_690041.2	Gene:	foxo6a / 561541	ZFINID:	ZDB-GENE-110914-126	Length:	594	Species:	Danio rerio

Alignment Length:	479	Identity:	164/479 - (34%)
Similarity:	220/479 - (45%)	Gaps:	109/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NGLAMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQN 81
            |..:.|.:..||.|::........|:.:..|.|....::.....|.|.|:.::
Zfish    30 NDFSCDVVNADLSLNLSIFQVDSDRAPSPSCRRRMMVLDAGGFHDLTGAALRK------------ 82

  Fly    82 ANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKN 146
                .|.|||||||||.|||:|||.||.|..||||||||||:|||:.||||||||||||||||||
Zfish    83 ----TKASSRRNAWGNQSYAELITRAIESTPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKN 143

  Fly   147 SIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRA-KKRVE 208
            |||||||||.||:|||||||||||||||||| .|.|||.||||.||:.. :..|.:||. :|:..
Zfish   144 SIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKLGKSQRRRAVSMDNGIKPLKSKGRTNRKKTT 208

  Fly   209 ALRQAGVVGLNDATPSPSSS-----VSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLS 268
            ..|:.....|.:...||.|.     |.:..|.:.:  |||.|           :||.::..|.||
Zfish   209 GKREQSTETLLEFCSSPDSGTGRIVVKDEFDTWTD--LHSLG-----------SSSTSTLSGHLS 260

  Fly   269 PIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGL-PSQPPPP 332
            ||..   |.:.|.|                              .::::..||:..| ||  |..
Zfish   261 PILG---EGELGEP------------------------------EERRKSCSASPRLFPS--PSS 290

  Fly   333 PYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTM 397
            .:.|..|          .|..|.. ..||.  |.||.|  |::.:   .|...|..|..|...|
Zfish   291 AHSPASH----------CPTDLRA-TIGYK--QHQSPC--HKNPH---YHYVSDIKSQGSSCET- 336

  Fly   398 SPAY------------PNSEPSSDSL---NTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLE 447
            .|.|            |.:|.:|.|:   :|..|::..||......|:..::.:.....:|..|.
Zfish   337 QPVYGLPDVGMHRSSIPTTEDNSGSMQGASTIQNLLTTGPQQFVKEMMHGKENEVHSMMVSQGLH 401

  Fly   448 DN--NCASTLIGQCLEVLNNEAQP 469
            .:  |.:|......::.|:.:.:|
Zfish   402 PSNPNTSSKPFHNIIQSLSQDHRP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	68/79 (86%)
foxo6a	XP_690041.2	FH	92..172	CDD:238016	68/79 (86%)
		PAT1	<390..>530	CDD:330585	6/36 (17%)
		FOXO-TAD	528..568	CDD:318811
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.020