Protein Alignment foxo and FOXP3

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_054728.2
• Gene: FOXP3 / 50943
• HGNCID: 6106
• Length: 431
• Species: Homo sapiens
• Alignment Length: 159
• Identity: 43/159 - (27%)
• Similarity: 66/159 - (41%)
• Gaps: 60/159 - (37%)

  Fly    91 RRNAWGN------------------------LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPY 131
            ||:.||:                        .:||.||..||..|.:|:.||::||.|..:...:
Human   309 RRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAF 373

  Fly   132 FKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPEAKPGKSVRRRAASMETSRY 196
            |:     |..|.|||:||||||||..|:||::|   |.:.|                 :::...:
Human   374 FR-----NHPATWKNAIRHNLSLHKCFVRVESE---KGAVW-----------------TVDELEF 413

  Fly   197 EKRRGRAKKRVEALRQAGVVGLNDATPSP 225
            .|:|.:...|           .::.||.|
Human   414 RKKRSQRPSR-----------CSNPTPGP 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	34/102 (33%)
FOXP3	NP_054728.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	68..76
		LXXLL motif. /evidence=ECO:0000269|PubMed:18354202	92..96
		Interaction with ZFP90. /evidence=ECO:0000269|PubMed:23543754	106..198
		Essential for transcriptional repressor activity and for interaction with KAT5 and HDAC7. /evidence=ECO:0000269|PubMed:17360565	106..190
		Interaction with IKZF4. /evidence=ECO:0000250|UniProtKB:Q99JB6	149..199
		FOXP-CC	193..260	CDD:465036
		Leucine-zipper	239..260
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	239..248
		Interaction with RUNX1. /evidence=ECO:0000269|PubMed:17377532	278..336		4/26 (15%)
		FH_FOXP3	337..417	CDD:410840	34/104 (33%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22678915	414..417		1/2 (50%)