Protein Alignment foxo and foxo3a

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001009988.1
• Gene: foxo3a / 494532
• ZFINID: ZDB-GENE-050116-1
• Length: 643
• Species: Danio rerio
• Alignment Length: 663
• Identity: 214/663 - (32%)
• Similarity: 302/663 - (45%)
• Gaps: 181/663 - (27%)

  Fly    24 LGGDLPLDVGFEPQTRARSNTWPCPRPEN---FVEPTD-------ELD----------------- 61
            |..|:.:|..||||.|.||.|||.||||:   ..||:|       |:|
Zfish     9 LAVDVDIDPDFEPQKRPRSCTWPLPRPESNSGKAEPSDVGIIPEEEVDENGTDDACASGDITGAS 73

  Fly    62 ---------------------STKASNQQL--APGDSQQAIQNANAA----------KKNSSRRN 93
                                 :..|:::.:  :||.||.|:...:.:          :|:|:|||
Zfish    74 KPASVTEGDPSSAAALPAIETNASANDKDIYGSPGSSQHALAACSDSSINGLIPQQPRKSSARRN 138

  Fly    94 AWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRF 158
            ||||.|||||||.||.|:.:|||||:|||:|||:||||||||||||||||||||||||||||:||
Zfish   139 AWGNYSYADLITQAIESSPEKRLTLAQIYDWMVRNVPYFKDKGDSNSSAGWKNSIRHNLSLHSRF 203

  Fly   159 MRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETSR--YEKRRGRAKKRVEALRQAGVVGLND 220
            :||||||||||||||:||: .|.||:.||||.||:.|.  .:..||||.|:..|| ||...|.::
Zfish   204 VRVQNEGTGKSSWWMVNPDGGKGGKAPRRRAVSMDNSNKLIKSARGRAAKKKAAL-QASQDGSSE 267

  Fly   221 A-------TPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASS-CGRLSPIRAQ---D 274
            :       |.||:|..|:.||.:              .|||.|.:||||: .||||||.|.   |
Zfish   268 SSSSLSKWTGSPTSRSSDELDAW--------------TDFRSRTNSNASTLSGRLSPILANLEVD 318

  Fly   275 LEPDWGFPVD---YQ-------NTTMTQAHAQALEELTGTM--------------ADELTLCNQQ 315
            ..||...|:.   |.       :|.:|:  ...|.:|.|||              .|.::|...|
Zfish   319 EVPDDDSPLSPMLYSSPSSMSPSTGLTE--LPRLADLAGTMNLNDGLSDNLMDDLLDNISLTASQ 381

  Fly   316 QQGFSAASGLPSQPPP-------------------------PPYQPPQHQQAQQ--QQQQQSPYA 353
            ..|.. .||...|..|                         ||......|...|  |:.:|:.::
Zfish   382 SPGHD-ESGANLQGSPVFTFSCSGSSLAIPSGSYGTNSLFSPPSVTGLRQSPMQTIQENKQATFS 445

  Fly   354 LNG--------------PASGYNTLQPQSQCLLHRSLNCSCMHNAR------DGLSPNSVTTTMS 398
            ...              .:|..:.|..||..|:.::.......|||      |.:..|.......
Zfish   446 CGSLFSEQSLQDLLSSESSSRSDVLLTQSDPLMSQASASVSSQNARRILLRNDPMMSNQAGPAGQ 510

  Fly   399 PAYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCASTLIGQCLEVL 463
            .....:.||...:    |.|....:|..:||    :|.||....|.|::.|:..|.|.|....|.
Zfish   511 AGLKKASPSGWRM----NCVPSSESDYQSLM----KQLQQSPFRSTSMQLNSSDSLLAGLNGSVT 567

  Fly   464 NNEAQPIDEF----NLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSI 524
            :.::...|.|    :||.|. |:.:|:::.:.:.::.....|:::.     :::|::|.:..|:.
Zfish   568 SAQSVSQDRFSSDLDLEAFS-GSFDCDMDIITRNDLMDAEGLELSF-----DSHLISSQNANLTS 626

  Fly   525 SNISNLSNISSNS 537
            .:.|.....||.|
Zfish   627 GSFSRTKRTSSQS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	68/79 (86%)
foxo3a	NP_001009988.1	FH	140..220	CDD:238016	68/79 (86%)
		FOXO_KIX_bdg	417..492	CDD:293280	13/74 (18%)
		FOXO-TAD	576..615	CDD:293281	7/44 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4171
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm24727
orthoMCL	1	0.900	-	-		OOG6_108778
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830