DRSC/TRiP Functional Genomics Resources

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Protein Alignment foxo and foxo1

DIOPT Version :9

Sequence 1:NP_001262557.1 Gene:foxo / 41709 FlyBaseID:FBgn0038197 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001008016.1 Gene:foxo1 / 493378 XenbaseID:XB-GENE-482528 Length:626 Species:Xenopus tropicalis


Alignment Length:636 Identity:210/636 - (33%)
Similarity:296/636 - (46%) Gaps:164/636 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LDVGFEPQTRARSNTWPCPRPE------------------------------NFVEPTDELDSTK 64
            :|..|||.:|.||.|||.||||                              :.:|.:::.|..:
 Frog    14 VDPDFEPFSRPRSCTWPLPRPEFNPSSSANSSPAPSLQPEPAAGNVDFLSNLSLLEESEDFDPAE 78

  Fly    65 A-----------------------SNQQ------------LAPGDSQQAIQNANAAKKNSSRRNA 94
            |                       ..||            |:|..|...:......|.:||||||
 Frog    79 ALGVCGDFPCQDIRQLQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRNA 143

  Fly    95 WGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFM 159
            ||||||||||:.||.|:.:|||||||||:|||::|||||||||||||||||||||||||||::|:
 Frog   144 WGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFV 208

  Fly   160 RVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGRAKKRVEALRQAGVVGLNDAT 222
            |||||||||||||:|||| .|.|||.|||||||: .|::.|.||||.|: :|..|:...|.:|  
 Frog   209 RVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMDNNSKFAKSRGRAAKK-KATMQSSQDGSSD-- 270

  Fly   223 PSPSSSVSEGLDHFPESP-LHSGGGFQLSPDFRQRASSNASS-CGRLSPIRAQDLEPDWG----- 280
             ||.|..|:    :|.|| ..|...|:....||.|.|||||: .||||||..:  :.|.|     
 Frog   271 -SPGSQFSK----WPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLSPIMPE--QDDLGDADVH 328

  Fly   281 ---FPVDYQNTTMT------QAHAQALEEL----------TGTMADELTLCNQQQQGF---SAAS 323
               :|......|.|      ..:::.:|.|          |.|.:...::  .||.|:   |..:
 Frog   329 NLVYPPSATKLTSTLPSLSEMGNSENMENLLDNLNLLSPNTSTQSSPASM--MQQSGYLFTSPNT 391

  Fly   324 GLPSQPPPPPYQPPQHQQAQQQQQQQSP-YALNGPASGYNTL--QPQSQCLLHRSLNC-SCMHN- 383
            .|.|  |...|:...:.|.......|.| ..:....|||..:  .|....||...|.. |..|| 
 Frog   392 SLGS--PNSEYRKYSYAQTGMNPVSQMPMQTVPENKSGYRAVGQYPVPAGLLKELLTSDSPPHND 454

  Fly   384 -----------------ARDGL-SPNSVTTT---------MSPAYPNSE---PSSDSLN----TY 414
                             |::.| :|:||..|         || ::|:|.   |:..|:|    |:
 Frog   455 ILTPVDSAVSQANSRVLAQNSLMAPSSVMPTYGSQPTHNKMS-SHPHSHQPPPNHPSVNGRTMTH 518

  Fly   415 SNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCASTLIGQC-LEVLNNEAQPIDEFNLENF 478
            ::.:  ....|....||....|..|.....|...|:|..  .|:. :..::.|..|.|   |::.
 Frog   519 NSGI--NRLSTVKTSVQVPMPQPIQMTSMGSYPVNSCNG--YGRVGIVSIHQEILPSD---LDDM 576

  Fly   479 PVGNLECNVEELLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSISNISN 529
            .:.:|:|::|.:::.::...|..|.|.      .:::.:.|.|.|::..::
 Frog   577 FIESLDCDMESIIRNDLMEDGEADFNF------DSILPNQSFPHSVTTTTH 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
foxoNP_001262557.1 FH 95..175 CDD:238016 66/79 (84%)
foxo1NP_001008016.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 14/42 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..142 9/51 (18%)
FH_FOXO1 135..233 CDD:410834 79/97 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..319 53/110 (48%)
FOXO_KIX_bdg 402..475 CDD:406960 14/72 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..519 9/35 (26%)
FOXO-TAD 569..606 CDD:406961 9/45 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 153 1.000 Domainoid score I4245
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 230 1.000 Inparanoid score I3363
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1160384at2759
OrthoFinder 1 1.000 - - FOG0000837
OrthoInspector 1 1.000 - - otm48265
Panther 1 1.100 - - O PTHR45767
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4575
SonicParanoid 1 1.000 - - X489
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1111.100

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