Protein Alignment foxo and FOXB2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001013757.1
• Gene: FOXB2 / 442425
• HGNCID: 23315
• Length: 432
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 63/345 - (18%)
• Similarity: 113/345 - (32%)
• Gaps: 139/345 - (40%)

  Fly    62 EELSKLIHK------TILDAGNNAKLGNLAKFIQRRSQLF--------------------YHMSF 100
            |||  |.||      |..|  |....|.|.|...:..::|                    |..|:
Human   304 EEL--LSHKEEDKSQTSFD--NLTPSGTLGKDYHKSVEIFPLKARKSMEKEDYEAPGNDDYRGSY 364

  Fly   101 ETIVSRENF---------------AISTHYHGTHSCRVHDNNLYYLVYETPVQYDPFNM------ 144
            .|::|:..|               .|..|                 :|..|:..:...:
Human   365 NTVLSQSLFEKQDQEGLASAGSKLTIQEH-----------------MYHVPLSPEKEQLLDRRPT 412

  Fly   145 -----KTEDYL---------------ASIDSADPLGSTK-------PAN---LRGDFPDVREDST 179
                 ::.|:|               :|:|..:.....|       ||:   |.||...|.:...
Human   413 ECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLV 477

  Fly   180 AGEDLSVQPSIGNI---LQYPNKFAWPDPDEEVSKKIMLAEQDAIRSINE------------LME 229
            ...|..::  ||.:   |..|:...:|.|..::..:.:.::..:.:.:.|            :.|
Human   478 VPADQQLE--IGRLQAELSNPHAGIFPHPSSQIQGQPLSSQAISQQHLQEAGAREWSSQSASMSE 540

  Fly   230 SVTEISVMNSGAV--VNSTDSLNITE---IELPNPTPIP-----------RNFANLREKDRLPEN 278
            |::..:.:|..|:  :||...| :||   :||....|:|           |:.|::|       :
Human   541 SLSIPASLNDAALAQMNSEVQL-LTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVR-------H 597

  Fly   279 THCDKERKDGNRCCDGRLAS 298
            ::.|.:|...|...|..|.|
Human   598 SYIDLQRAGRNGSNDASLDS 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	19/129 (15%)
FOXB2	NP_001013757.1	FH_FOXB2	1..110	CDD:410817
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..220
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..432		2/18 (11%)