DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment foxo and FOXO4

DIOPT Version :9

Sequence 1:	NP_001262557.1	Gene:	foxo / 41709	FlyBaseID:	FBgn0038197	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_005929.2	Gene:	FOXO4 / 4303	HGNCID:	7139	Length:	505	Species:	Homo sapiens

Alignment Length:	562	Identity:	191/562 - (33%)
Similarity:	249/562 - (44%)	Gaps:	162/562 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPLDVGFEPQTRARSNTWPCPRPENFVEPT----------DELDSTKASNQQLAP-------GDS 75
            :.||..||||:|.||.|||.||||...:|:          :::.:...|...|.|       |..
Human    16 IDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGP 80

  Fly    76 QQAIQNA-NAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSN 139
            |..|..| ...:|..||||||||.|||:||:.||.||.:|||||:|||||||:.|||||||||||
Human    81 QPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSN 145

  Fly   140 SSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRGR 202
            ||||||||||||||||::|::|.||.|||||||||||| .|.||:.|||||||: :|:..:.|.:
Human   146 SSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSK 210

  Fly   203 AKKRVEALRQAGVVGLNDATP---------SPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRAS 258
            |.|:..::..|...|....:|         ||.|...|..|              :...||.|:|
Human   211 APKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEAD--------------MWTTFRPRSS 261

  Fly   259 SNASSCG-RLSPIR------AQDLEPD-----WGFP---------VDYQNTTMTQAHAQ------ 296
            |||||.. ||||:|      |:::...     .|.|         :|..|  :|.:|:.
Human   262 SNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLN--LTSSHSLLSRSGL 324

  Fly   297 ---ALEE--LTGTM-ADELTLCNQQQQGFSAASG-----------LPSQPPPPPYQPPQHQQAQQ 344
               :|:.  :||.: ....:|.:..:...||..|           |.|..||||        |..
Human   325 SGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPP--------ADV 381

  Fly   345 QQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGL--------SPNSVTTTMS--- 398
            ...|..|.....|     ||      ||...|..|.......||        .|:|:..|:|
Human   382 LMTQVDPILSQAP-----TL------LLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIA 435

  Fly   399 -PAYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCASTLIGQCLEV 462
             |....|.|...:|.|   .||..|.:.|:     |.:..|...|...:|
Human   436 PPPVMASAPIPKALGT---PVLTPPTEAAS-----QDRMPQDLDLDMYME--------------- 477

  Fly   463 LNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDIN 504
                               ||||:::.::...|..|..||.|
Human   478 -------------------NLECDMDNIISDLMDEGEGLDFN 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	63/79 (80%)
FOXO4	NP_005929.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..100		28/83 (34%)
		Trypan_PARP	<4..83	CDD:114603	22/66 (33%)
		FH	101..181	CDD:238016	63/79 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..246		28/69 (41%)
		FOXO_KIX_bdg	<358..395	CDD:293280	11/49 (22%)
		FOXO-TAD	465..503	CDD:293281	12/70 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12001
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm41061
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4575
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960