Protein Alignment foxo and FOXA2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_068556.2
• Gene: FOXA2 / 3170
• HGNCID: 5022
• Length: 463
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 101/396 - (25%)
• Similarity: 149/396 - (37%)
• Gaps: 114/396 - (28%)

  Fly    65 ASNQQLAPGDSQQAIQNANAAKK-NSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQN 128
            |:...::|...|..:..|...|. ..|..:|....||..|||.||..:.:|.||||:||:|::..
Human   134 ANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDL 198

  Fly   129 VPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEAKPGKSVRRRAASM 191
            .|:::     .:...|:|||||:||.::.|::|..  :..||.|:|.|:|::         ....
Human   199 FPFYR-----QNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDS---------GNMF 249

  Fly   192 ETSRYEKRRGRAK-----------------KRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPES 239
            |...|.:|:.|.|                 |:..|..||....|.:|. .|:|....|    .||
Human   250 ENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAA-GPASETPAG----TES 309

  Fly   240 PLHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQ-ALEELTG 303
            |                 .|:||.|                           |.|.: .|.||.|
Human   310 P-----------------HSSASPC---------------------------QEHKRGGLGELKG 330

  Fly   304 TMADELT------LCNQQQQGFSAASGLPSQP--PPPPYQPPQHQQAQQQQQQQSPYALNGPASG 360
            |.|..|:      ...||||..:...|.|..|  ||..:..|:|.           ||.|.|.|.
Human   331 TPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHH-----------YAFNHPFSI 384

  Fly   361 YNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMS-PAYPNSEPSSDSLNTYSNVV-LDG-- 421
            .|.:..:.|  .|.|.:    |:....:...:....|. |.|.:..|.|.::...:|.. ||.
Human   385 NNLMSSEQQ--HHHSHH----HHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASP 443

  Fly   422 -PADTA 426
             .|||:
Human   444 LAADTS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	30/80 (38%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	6/29 (21%)
		FH_FOXA2	163..264	CDD:410813	38/114 (33%)
		HNF_C	379..452	CDD:430552	19/77 (25%)