Protein Alignment foxo and FOXA1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_004487.2
• Gene: FOXA1 / 3169
• HGNCID: 5021
• Length: 472
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 97/408 - (23%)
• Similarity: 163/408 - (39%)
• Gaps: 83/408 - (20%)

  Fly    33 GFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAKKNSSRRNAWGN 97
            |..|...|.:   ||..|..:. |:: |..::|.    ..||::...::...||.         .
Human   126 GLGPYAAAMN---PCMSPMAYA-PSN-LGRSRAG----GGGDAKTFKRSYPHAKP---------P 172

  Fly    98 LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQ 162
            .||..|||.||..|..|.||||:||:|::...||::     .:...|:|||||:||.::.|::|.
Human   173 YSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR-----QNQQRWQNSIRHSLSFNDCFVKVA 232

  Fly   163 N--EGTGKSSWWMLNPEA----KPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDA 221
            .  :..||.|:|.|:|::    :.|..:||:    :..:.||:.|...........:|..|..::
Human   233 RSPDKPGKGSYWTLHPDSGNMFENGCYLRRQ----KRFKCEKQPGAGGGGGSGSGGSGAKGGPES 293

  Fly   222 TPSPSSSVSEGLDHFPESPLHSG-----GGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDWGF 281
            ...||.:.:...|    ||||.|     |..:.:|     |...|:|...|
Human   294 RKDPSGASNPSAD----SPLHRGVHGKTGQLEGAP-----APGPAASPQTL-------------- 335

  Fly   282 PVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPSQPPP---PPYQPPQHQQAQ 343
              |:...|.| ..|..|:....:.|..::      .|..|.:.:|:..|.   .|::...|.:..
Human   336 --DHSGATAT-GGASELKTPASSTAPPIS------SGPGALASVPASHPAHGLAPHESQLHLKGD 391

  Fly   344 QQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSV------TTTMSPAYP 402
            .......|:::|...|.    ..|...|..::...:..::......|.|:      .||.||..|
Human   392 PHYSFNHPFSINNLMSS----SEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEP 452

  Fly   403 NSEPSSDSLNTYSNVVLD 420
            ::...:.....||..||:
Human   453 SALEPAYYQGVYSRPVLN 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	32/80 (40%)
FOXA1	NP_004487.2	Forkhead_N	17..169	CDD:369872	11/51 (22%)
		FH_FOXA1	157..268	CDD:410812	41/128 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..392		31/154 (20%)
		HNF_C	397..461	CDD:430552	12/67 (18%)