Protein Alignment foxo and foxa1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_571359.2
• Gene: foxa1 / 30541
• ZFINID: ZDB-GENE-990415-78
• Length: 427
• Species: Danio rerio
• Alignment Length: 371
• Identity: 99/371 - (26%)
• Similarity: 152/371 - (40%)
• Gaps: 67/371 - (18%)

  Fly    18 GLAMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASN--QQLAPGDSQQ--A 78
            |.||:.:||      |......|.|       |.|....|.:..|..|.|  ..::|..|..  |
Zfish    85 GGAMNGMGG------GVSSMGTALS-------PSNLNAMTAQHSSMNALNPYTSMSPTMSSMTYA 136

  Fly    79 IQNANAAKKNSSRRNAWGN----LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSN 139
            ..|.|.|:.|.:.|.::.:    .||..|||.||..|..|.||||:||:|::...||::     .
Zfish   137 QPNLNRARDNKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR-----Q 196

  Fly   140 SSAGWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEAKPGKSVRRRAASMETSRYEKRRGR 202
            :...|:|||||:||.::.|::|..  :..||.|:|.|:|::         ....|...|.:|:.|
Zfish   197 NQQRWQNSIRHSLSFNDCFVKVSRSPDKPGKGSYWTLHPDS---------GNMFENGCYLRRQKR 252

  Fly   203 AK--------KRVEALRQAGVVGLNDATPSPSS-SVSEGLDHFPESPLHSGGGFQLSPDFRQRAS 258
            .|        ||.|..|:.     :..:.||:| |.|....|...|.:.|.......|....|:.
Zfish   253 FKCDKKLPDGKRSEGKREQ-----SSGSGSPASDSTSSKPVHMDSSSITSSNQSSSPPSLDHRSG 312

  Fly   259 SNASSCGRLSPIRAQDLEPDWGFP-VDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAA 322
            |:|:|            |...|.| |...:|:::..|:.|.|.......|.....|..   ||..
Zfish   313 SSANS------------ELKSGGPQVHPVSTSLSSLHSMAHESQLHLKGDPHYSFNHP---FSIN 362

  Fly   323 SGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQS 368
            :.:.|.......:...::||.|.....|..:.|.|.:|..::.|.:
Zfish   363 NLMSSSEQQHKLELKAYEQALQYSSYGSGMSSNLPMAGRASMDPSA 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	32/84 (38%)
foxa1	NP_571359.2	Forkhead_N	17..156	CDD:369872	22/83 (27%)
		FH_FOXA1	145..255	CDD:410812	40/123 (33%)
		HNF_C	356..416	CDD:430552	12/56 (21%)