Protein Alignment foxo and foxo3b

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_571160.1
• Gene: foxo3b / 30296
• ZFINID: ZDB-GENE-990708-6
• Length: 651
• Species: Danio rerio
• Alignment Length: 673
• Identity: 214/673 - (31%)
• Similarity: 284/673 - (42%)
• Gaps: 198/673 - (29%)

  Fly    27 DLPLDVGFEPQTRARSNTWPCPR--------------PENFVEPTDELDSTKASNQQ-LAPGD-- 74
            |:.:|..||||.|.||.|||.|.              ||   |..||.||....|.. :..|:
Zfish    13 DIAIDPDFEPQKRPRSCTWPLPESSMAKPASNDTDIIPE---EEDDEDDSAMTINANGMGEGEDN 74

  Fly    75 ----------------------SQQAIQNANAA----------KKNSSRRNAWGNLSYADLITHA 107
                                  |.||.....|:          :|:|||||||||||||||||.|
Zfish    75 GSPSLAEELISINGQENTGSPLSSQAASATTASPEVASQQQTPRKSSSRRNAWGNLSYADLITKA 139

  Fly   108 IGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWW 172
            |.|..||||||||||:|||.:|||||||||||||||||||||||||||:||:|||||||||||||
Zfish   140 IESTPDKRLTLSQIYDWMVSSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRVQNEGTGKSSWW 204

  Fly   173 MLNPE-AKPGKSVRRRAASMET-SRYEK-RRGRAKKRVEALRQAGVVGLNDATPSPSSSVSEGLD 234
            |:||| .:.||:.||||.||:. ::|.| .||||.|:..||:.|....|.:.:       :.||.
Zfish   205 MINPEGGRGGKAPRRRAVSMDNGNKYTKTARGRAAKKKAALQAAQEGSLENIS-------AGGLS 262

  Fly   235 HFPESPLHSGGGFQLS--PDFRQRASSNASS-CGRLSPIRAQDLEPD-----------WGFPVDY 285
            .:|.||.......|.|  .|||.|.:||||: .||||||.|.....|           :..|...
Zfish   263 KWPGSPTSRSSDEQESCWTDFRSRTNSNASTVSGRLSPILANPELDDVSDGPPLSPILYSSPSSL 327

  Fly   286 QNTTMTQAHAQ-------ALEELTGTM----ADEL---TLCN--------QQQQGFSAASGLPSQ 328
            ...:.|.::::       .|.:|||||    ||.|   .|.|        |:...||..|...:.
Zfish   328 SPPSSTSSNSKTCPGELPVLADLTGTMNLNEADNLMVDLLDNIATQVQVVQESSPFSFGSKSTAS 392

  Fly   329 PP---------------------PPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLL 372
            ||                     |.|....|......|:.:|:.:      |..:..:...|.||
Zfish   393 PPSTSTSQTVSNNTGGFSNPIFGPSPGSLRQKPMQTIQENKQTSF------SSISCFETSLQDLL 451

  Fly   373 HRSLNCSCMHN-----ARDGLSPNSVTTTMSPAY---PNSEPSSDSLNTYSNVVLDGPADTAALM 429
            :.....|..|:     ..|.|...:.....|..|   .|....:|.:.:..:.||:|   .:..:
Zfish   452 NSDSLVSHSHSDVMMTQSDPLISQASAAVTSQNYRLRNNPMLRNDPMMSSFSSVLNG---RSGHL 513

  Fly   430 VQQQQQQQQQQQLSASLEDNNCASTLIGQCLEVLNN--------EAQP----------------- 469
            ..:|..|....|.|.....||.|.:|:...    ||        :.||
Zfish   514 QNKQHHQGSNGQGSLRSLSNNRAQSLVNDA----NNLVSAKQLLQPQPTMLMTETPLYSGMNGSN 574

  Fly   470 ------------------IDEFNLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVNTNLVN 516
                              :|.||      |:|:|:|:.:::.|:.....||.|......|.
Zfish   575 GLGICHPSGTDRFPSDLDLDIFN------GSLDCDVDSIIRSELMDSDGLDFNFDALMQNA---- 629

  Fly   517 SSSGPLSISNISNLSNISSNSGS 539
                 :|::.:.|.:....::.|
Zfish   630 -----VSLNPVGNFTGTKQSNHS 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	69/78 (88%)
foxo3b	NP_571160.1	FH_FOXO1	118..216	CDD:410834	81/97 (84%)
		FOXO_KIX_bdg	411..493	CDD:465228	16/87 (18%)
		FOXO-TAD	586..624	CDD:435506	11/43 (26%)