Protein Alignment foxo and Foxo4

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001100413.1
• Gene: Foxo4 / 302415
• RGDID: 1561201
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 182/586 - (31%)
• Similarity: 247/586 - (42%)
• Gaps: 186/586 - (31%)

  Fly    16 DNGLAMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQL---------- 70
            :|..:..:....:.||..||||:|.||.|||.||||...||.:..:...:..|::
  Rat     4 ENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEPPEPSEVEPSLGQKVPTEGHSEPTL 68

  Fly    71 --------APGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQ 127
                    |.|...:.:......:|..||||||||.|||:||:.||.||.:|||||:|||||||:
  Rat    69 LPSRLPEPAGGPQPEILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVR 133

  Fly   128 NVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASM 191
            .|||||||||||||||||||||||||||::|::|.||.|||||||||||: .|.||:.|||||||
  Rat   134 TVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASM 198

  Fly   192 ETSRYEKRRGRA---KKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSP-- 251
            ::|. :..|||:   ||:...|            |:|....:      |.|||.....:..||
  Rat   199 DSSS-KLLRGRSKGPKKKPSVL------------PAPPEGAT------PRSPLGHFAKWSSSPCP 244

  Fly   252 ----------DFRQRASSNASSCG-RLSPIR--------------------------AQDLEPDW 279
                      .||.|:|||||:.. ||||:|                          ::|||...
  Rat   245 RNREEADVWTTFRPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLD 309

  Fly   280 GFPVDYQNTTMTQAHAQALE---------------ELTGTMADELTL---CNQQQQGFSAASGLP 326
            |..:...::.:::::..:..               .|.|.:...|:.   |....|...|.  |.
  Rat   310 GLNLASPHSLLSRSNLSSFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEAL--LT 372

  Fly   327 SQPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTL-----QPQSQCLLHRSLNCSCMHNARD 386
            |..||||        |.....|..|.....|     ||     .|.|..|   :...|......:
  Rat   373 SDTPPPP--------ADVLMTQVDPILSQAP-----TLLLLGGMPSSSKL---ATGVSLCPTPLE 421

  Fly   387 GLSPNSVTTTMS-----PAYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASL 446
            |..|:::..|:|     |..|.: |....|.|
  Rat   422 GPGPSNLVPTLSVMAPPPVMPGA-PIPKVLGT--------------------------------- 452

  Fly   447 EDNNCASTLIGQCLEVLNNEAQPIDEFNLENFP--------VGNLECNVEELLQQEMSYGGLLDI 503
                          .||   |.|.::|:.:..|        :.||||:::.::...|...| ||.
  Rat   453 --------------PVL---ASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEG-LDF 499

  Fly   504 N 504
            |
  Rat   500 N 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	62/78 (79%)
Foxo4	NP_001100413.1	FH_FOXO4	98..183	CDD:410836	68/84 (81%)
		FOXO_KIX_bdg	<359..399	CDD:465228	15/54 (28%)
		FOXO-TAD	466..503	CDD:435506	10/36 (28%)