Protein Alignment foxo and Foxo4

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001100413.1
• Gene: Foxo4 / 302415
• RGDID: 1561201
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 182/586 - (31%)
• Similarity: 247/586 - (42%)
• Gaps: 186/586 - (31%)

  Fly    16 DNGLAMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQL---------- 70
            :|..:..:....:.||..||||:|.||.|||.||||...||.:..:...:..|::
  Rat     4 ENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEPPEPSEVEPSLGQKVPTEGHSEPTL 68

  Fly    71 --------APGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQ 127
                    |.|...:.:......:|..||||||||.|||:||:.||.||.:|||||:|||||||:
  Rat    69 LPSRLPEPAGGPQPEILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVR 133

  Fly   128 NVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASM 191
            .|||||||||||||||||||||||||||::|::|.||.|||||||||||: .|.||:.|||||||
  Rat   134 TVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASM 198

  Fly   192 ETSRYEKRRGRA---KKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSP-- 251
            ::|. :..|||:   ||:...|            |:|....:      |.|||.....:..||
  Rat   199 DSSS-KLLRGRSKGPKKKPSVL------------PAPPEGAT------PRSPLGHFAKWSSSPCP 244

  Fly   252 ----------DFRQRASSNASSCG-RLSPIR--------------------------AQDLEPDW 279
                      .||.|:|||||:.. ||||:|                          ::|||...
  Rat   245 RNREEADVWTTFRPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLD 309

  Fly   280 GFPVDYQNTTMTQAHAQALE---------------ELTGTMADELTL---CNQQQQGFSAASGLP 326
            |..:...::.:::::..:..               .|.|.:...|:.   |....|...|.  |.
  Rat   310 GLNLASPHSLLSRSNLSSFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEAL--LT 372

  Fly   327 SQPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTL-----QPQSQCLLHRSLNCSCMHNARD 386
            |..||||        |.....|..|.....|     ||     .|.|..|   :...|......:
  Rat   373 SDTPPPP--------ADVLMTQVDPILSQAP-----TLLLLGGMPSSSKL---ATGVSLCPTPLE 421

  Fly   387 GLSPNSVTTTMS-----PAYPNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASL 446
            |..|:::..|:|     |..|.: |....|.|
  Rat   422 GPGPSNLVPTLSVMAPPPVMPGA-PIPKVLGT--------------------------------- 452

  Fly   447 EDNNCASTLIGQCLEVLNNEAQPIDEFNLENFP--------VGNLECNVEELLQQEMSYGGLLDI 503
                          .||   |.|.::|:.:..|        :.||||:::.::...|...| ||.
  Rat   453 --------------PVL---ASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEG-LDF 499

  Fly   504 N 504
            |
  Rat   500 N 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	63/79 (80%)
Foxo4	NP_001100413.1	FH_FOXO4	98..183	CDD:410836	68/84 (81%)
		FOXO_KIX_bdg	<359..399	CDD:406960	15/54 (28%)
		FOXO-TAD	466..503	CDD:406961	10/36 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11270
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm45200
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.880